# ALCOHOL (alcohol) — Global Cosmetic Regulatory & Formulation Monograph

- **Canonical URL**: https://www.inciname.com/en/ingredients/alcohol
- **Standard INCI**: `ALCOHOL`
- **KR MFDS Standard Name**: `에탄올`
- **CAS No.**: `64-17-5`
- **EC / EINECS No.**: `200-578-6`
- **Origin**: `synthetic`
- **Functions**: 항균제, 수렴제, 향료, 용제, 소포제, 점도조절제
- **Molecular Formula / MW**: `—` (— g/mol)

## 1. 7-Track Official Regulatory Label Names
| Track | Official Label Nomenclature |
| :--- | :--- |
| KR (MFDS Standard) | 에탄올 |
| KR (Former Names) | 알코올 |
| EU (CosIng 1223/2009) | ALCOHOL |
| US (PCPC / MoCRA INCI) | ALCOHOL |
| US (FDA OTC Monograph) | ALCOHOL (ETHANOL) |
| CN (NMPA IECIC) | 乙醇 |
| JP (JCIA / MHLW QD) | エタノール (QD: エタノール) |

## 2. Layer 1 — Global 6-Region Statutory Summary
- **KR (MFDS)**: `none`
- **EU (1223/2009)**: `none`
- **US (FDA/MoCRA)**: `none`
- **CN (NMPA IECIC)**: `allowed` (Entry: `7676`)
- **JP (MHLW)**: `none`
- **ASEAN (ACD)**: `none`



## 3. Layer 2 — Toxicological & Historical Safe Use Concentrations
- Listed within general cosmetic GMP safety thresholds.

## 4. Layer 3 — Formulation Quartiles & Compatibility
- **Optimal pH Window**: 4 – 8
- **Max Process Temp**: ≤ 50°C
- **Synergy Pairings**: GLYCERIN, CAPRYLIC/CAPRIC TRIGLYCERIDE, TOCOPHEROL
- **Incompatibilities**: Verify phase compatibility under extreme pH or high electrolyte loads

## 5. Academic Monograph
■ [1. Chemical Identity & International Labeling Nomenclature]
  - INCI Name: ALCOHOL | CAS No.: 64-17-5 | EC No.: 200-578-6
  - Origin: SYNTHETIC | Functions: , , , , , 
  - Physicochemical Profile: Formula      | MW /(Polymer/Complex) | /   | Ionic Nature: non-ionic | CosIng/MFDS 
  - Official Regional Label Names: US [ALCOHOL] · EU [ALCOHOL] · CN [乙醇] · JP [エタノール] · JP Quasi-Drug [エタノール]
■ [2. Dermatological Mechanism of Action & Functional Role]
  - Alcohol is undenatured ethyl alcohol that conforms to the formula: Classified under origin 'synthetic', it acts within the cosmetic vehicle or stratum corneum to deliver , , , , ,  performance and structural formulation stability.
■ [3. Global 6-Jurisdiction Regulatory Status & Safety Limits (Layer 1 & Layer 2)]
  - Regional Summary: KR: NONE | EU: NONE | US: NONE | CN: ALLOWED | JP: NONE | ASEAN: NONE (CN IECIC (2025) Entry No. 7676 (乙醇))
  - No specific Annex prohibition or numeric restriction across the 6 major jurisdictions (Permitted under general GMP safety assessment).
  - Official Safety & Historical Use Concentration (Layer 2): Quantum satis (QS) within standard cosmetic safety margins
■ [4. Formulation Dosage Guide by Product Category (Layer 3-A)]
  - [aqueous_serum] Typical range: 1.0 ~ 37.5% (Median 35.0%, Ref: Global Starter Formulation Library Statistical Distribution (n=5, SEPPIC 3 · GRANT 2)) — Aqueous serum, toner & hydrogel matrix formulation component
  - [emulsion_cream] Typical range: 3.0 ~ 68.0% (Median 38.0%, Ref: Global Starter Formulation Library Statistical Distribution (n=6, SEPPIC 6)) — Emulsion cream & lotion structural / conditioning agent
■ [5. Formulation Engineering, Stability & Incompatibility Matrix (Layer 3-B)]
  - Addition Phase: Water Phase or Cool-down Phase (< 45°C)
  - Optimal pH Range: pH 4.0 ~ 8.0 | Max Process Temp: Max 50°C | Electrolyte Tolerance: MEDIUM
  - Incompatibility / Caution: Verify phase compatibility under extreme pH or high electrolyte loads
  - Synergy Pairings: GLYCERIN, CAPRYLIC/CAPRIC TRIGLYCERIDE, TOCOPHEROL | Reference Trade Names: ALCOHOL
■ [6. Peer-Reviewed Literature & Official Compendia Evidence]
  - PMID 42318046 (2026, Infect Prev Pract): Observed practices in surgical site infection prevention in Ukraine: national survey results from 2021 and 2025
  - PMID 42317521 (2026, Mater Today Bio): Salidroside-loaded stem cell-derived artificial nanovesicles in hydrogel microneedles alleviate inflammation and enhance
  - PMID 42315088 (2026, Ann Hepatol): Asia-Pacific perspectives on the steatotic liver disease (SLD) reclassification: balancing terminology, diagnostic crite

## 6. Linked PubMed Literature
- [PMID: 42318046] Observed practices in surgical site infection prevention in Ukraine: national survey results from 2021 and 2025 — *Infect Prev Pract* (2026)
- [PMID: 42317521] Salidroside-loaded stem cell-derived artificial nanovesicles in hydrogel microneedles alleviate inflammation and enhance diabetic wound regeneration — *Mater Today Bio* (2026)
- [PMID: 42315088] Asia-Pacific perspectives on the steatotic liver disease (SLD) reclassification: balancing terminology, diagnostic criteria, and implementation — *Ann Hepatol* (2026)
- [PMID: 42307923] Commercial Price Variation for Common Dermatologic Procedures — *JAMA Dermatol* (2026)
- [PMID: 42304612] Pruritic Rash and Diarrhea in a Man with Chronic Alcohol Use Disorder — *Br J Dermatol* (2026)
- [PMID: 42298517] Efficacy of chlorhexidine in alcohol versus aqueous povidone-iodine for preoperative skin antisepsis in preventing surgical site infections: a systematic review and meta-analysis with trial sequential analysis — *BMC Surg* (2026)
- [PMID: 42294564] Prevalence of Steatotic Liver Disease with Fibrosis and Diagnostic Screening Tools in Patients with Psoriasis — *Acta Derm Venereol* (2026)
- [PMID: 42289613] Numerical modelling for hollow pyramidal microneedle-based drug-loaded particles delivery for controlled drug release — *Drug Deliv Transl Res* (2026)
- [PMID: 42284628] Selenium nanoparticle-and quercetin-embedded nanofibrous mats for enhanced cutaneous wound healing — *J Trace Elem Med Biol* (2026)
- [PMID: 42280700] Comparative Evaluation and Physicochemical Characterisation of Three Tolerant Interspecific Grape Cultivars — *Plants (Basel)* (2026)
- [PMID: 42279310] The Role of Chlorhexidine Gluconate (ChloraPrep™) in Reducing Surgical Site Infections After Ovarian Cancer Surgery — *Cancers (Basel)* (2026)
- [PMID: 42276321] Healthcare provider approaches to managing the health harms of xylazine: A qualitative study — *J Subst Use Addict Treat* (2026)