# ARGININE (arginine) — Global Cosmetic Regulatory & Formulation Monograph

- **Canonical URL**: https://www.inciname.com/en/ingredients/arginine
- **Standard INCI**: `ARGININE`
- **KR MFDS Standard Name**: `알지닌`
- **CAS No.**: `74-79-3`
- **EC / EINECS No.**: `200-811-1`
- **Origin**: `synthetic`
- **Functions**: 대전방지제, 향료, 모발컨디셔닝제, 피부컨디셔닝제
- **Molecular Formula / MW**: `—` (— g/mol)

## 1. 7-Track Official Regulatory Label Names
| Track | Official Label Nomenclature |
| :--- | :--- |
| KR (MFDS Standard) | 알지닌 |
| KR (Former Names) | — |
| EU (CosIng 1223/2009) | ARGININE |
| US (PCPC / MoCRA INCI) | ARGININE |
| US (FDA OTC Monograph) | — |
| CN (NMPA IECIC) | 精氨酸 |
| JP (JCIA / MHLW QD) | アルギ닌 (QD: Ｌ－アルギニン) |

## 2. Layer 1 — Global 6-Region Statutory Summary
- **KR (MFDS)**: `none`
- **EU (1223/2009)**: `none`
- **US (FDA/MoCRA)**: `none`
- **CN (NMPA IECIC)**: `allowed` (Entry: `3519`)
- **JP (MHLW)**: `none`
- **ASEAN (ACD)**: `none`



## 3. Layer 2 — Toxicological & Historical Safe Use Concentrations
- **cn_iecic_max** (leave_on): ≤ 3.8% — NMPA IECIC (2025) Entry 03418 (2025)
- **cn_iecic_max** (rinse_off): ≤ 3% — NMPA IECIC (2025) Entry 03418 (2025)

## 4. Layer 3 — Formulation Quartiles & Compatibility
- **Optimal pH Window**: 4.5 – 7.5
- **Max Process Temp**: ≤ 70°C
- **Synergy Pairings**: —
- **Incompatibilities**: —

## 5. Academic Monograph
Arginine is a component of pH-switchable artificial skin dressing that, modified with polydopamine into PtAu nanozymes, increases reactive oxygen species production in the acidic and hyperglycemic environment of infected diabetic wounds, effectively killing bacteria and disrupting biofilms.
As the wound environment shifts to neutral pH, the nanozyme activity changes to scavenge excess reactive oxygen species and release oxygen, reducing oxidative stress and improving local oxygen supply.
Arginine coordinates antibacterial, anti-inflammatory, antioxidant, and pro-regenerative effects to provide an integrated therapeutic platform for diabetic wound management.
Arginine-containing gel formulations statistically significantly increased microhardness values following remineralization of artificially demineralized enamel.
Arginine-containing formulations demonstrated statistically significantly higher calcium content compared to non-arginine formulations in energy dispersive X-ray analysis.
Arginine-containing formulations produced statistically significantly larger inhibition zones against both cariogenic and commensal bacterial species compared with arginine-free formulations in agar well diffusion assay.
Through synergy with ginger and eggshell extract, arginine provides enhanced enamel remineralization and antimicrobial efficacy.

## 6. Linked PubMed Literature
- [PMID: 42321517] Lysosome-derived methylated arginine is a signalling metabolite controlling the lipidome — *Nat Cell Biol* (2026)
- [PMID: 42243363] In vitro assessment of experimental bioactive tooth gel formulas containing L-arginine, ginger and eggshell for remineralization and anti-bacterial effect — *Sci Rep* (2026)
- [PMID: 42227285] Artificial Skin Dressing With pH-Switchable Nanozyme Activity for Bidirectional ROS Regulation in Infected Diabetic Wound Management — *Small* (2026)
- [PMID: 42176293] Regional cutaneous vasodilatory responses to local heating in post-menopausal females with and without hormone replacement therapy — *Skin Pharmacol Physiol* (2026)
- [PMID: 42317129] Nanostructure and Collagen-Stimulating Activity of Cationic Pentapeptide Lipopeptides — *J Pept Sci* (2026)
- [PMID: 42305355] Carrier-free targeted co-assembly of glycyrrhizin and puerarin overcomes ocular barriers for corneal alkali burn therapy via macrophage reprogramming — *Mater Today Bio* (2026)
- [PMID: 42295702] Guanidinium-rich scyllo-inositol molecular transporter enables enhanced transdermal and intracellular delivery of vitagen — *Drug Deliv Transl Res* (2026)
- [PMID: 42262449] Purification and characterization of arginase from a new Aspergillus niger AUMC16187 isolate from sandy soil — *Arch Microbiol* (2026)
- [PMID: 42215990] Mast cells release DNA Extracellular Traps (DETs) in response to SARS-CoV-2 and its spike protein — *Cell Commun Signal* (2026)
- [PMID: 42208397] Knowledge, attitudes and practices of healthcare professionals in nutritional management of patients with pressure ulcers: an online survey in Flanders and the Netherlands — *J Tissue Viability* (2026)
- [PMID: 42204138] PRELP negatively regulates IL-17A-mediated proliferation and the inflammatory response in psoriasis — *Signal Transduct Target Ther* (2026)
- [PMID: 42185976] Domestic pig skin peptides: targeted starvation therapy for gram-positive bacteria MRSA through ABC transporters — *BMC Microbiol* (2026)