# BAKUCHIOL (bakuchiol) — Global Cosmetic Regulatory & Formulation Monograph

- **Canonical URL**: https://www.inciname.com/en/ingredients/bakuchiol
- **Standard INCI**: `BAKUCHIOL`
- **KR MFDS Standard Name**: `바쿠치올`
- **CAS No.**: `10309-37-2`
- **EC / EINECS No.**: `N/A`
- **Origin**: `synthetic`
- **Functions**: 항균제, 항산화제, 피부컨디셔닝제, 에모리엔트
- **Molecular Formula / MW**: `C18H24O` (256.38 g/mol)

## 1. 7-Track Official Regulatory Label Names
| Track | Official Label Nomenclature |
| :--- | :--- |
| KR (MFDS Standard) | 바쿠치올 |
| KR (Former Names) | — |
| EU (CosIng 1223/2009) | BAKUCHIOL |
| US (PCPC / MoCRA INCI) | BAKUCHIOL |
| US (FDA OTC Monograph) | — |
| CN (NMPA IECIC) | — |
| JP (JCIA / MHLW QD) | バクチオール (QD: バクチオール) |

## 2. Layer 1 — Global 6-Region Statutory Summary
- **KR (MFDS)**: `none`
- **EU (1223/2009)**: `none`
- **US (FDA/MoCRA)**: `none`
- **CN (NMPA IECIC)**: `allowed` (Entry: `—`)
- **JP (MHLW)**: `none`
- **ASEAN (ACD)**: `none`



## 3. Layer 2 — Toxicological & Historical Safe Use Concentrations
- **cn_iecic_max** (leave_on): ≤ 2% — NMPA IECIC (2025) Entry 01195 (2025)
- **cn_iecic_max** (rinse_off): ≤ 1% — NMPA IECIC (2025) Entry 01195 (2025)

## 4. Layer 3 — Formulation Quartiles & Compatibility
- **Optimal pH Window**: 4.5 – 6.5
- **Max Process Temp**: ≤ 75°C
- **Synergy Pairings**: RETINOL, SQUALANE, CAPRYLIC/CAPRIC TRIGLYCERIDE, SODIUM PHYTATE, TOCOPHEROL
- **Incompatibilities**: Phenolic structure forms dark reddish-brown complexes with trace iron ions (Fe3+) or at alkaline pH (>7.0); always include 0.05~0.1% Sodium Phytate or Disodium EDTA and keep pH 5.0~6.0; Must use ≥99% purified grade depleted of phototoxic psoralens (<100 ppm)

## 5. Academic Monograph
■ [1. Chemical Identity & International Labeling Nomenclature]
  - INCI Name: BAKUCHIOL | CAS No.: 10309-37-2 | EC No.: N/A
  - Origin: SYNTHETIC | Functions: , , , 
  - Physicochemical Profile: Formula C18H24O | MW 256.38 g/mol | LogP 5.09 | Ionic Nature: non-ionic | PubChem CID 5468522
  - Official Regional Label Names: US [BAKUCHIOL] · EU [BAKUCHIOL] · CN [-] · JP [バクチオール] · JP Quasi-Drug [バクチオール]
■ [2. Dermatological Mechanism of Action & Functional Role]
  - Botanical meroterpene phenol isolated from Psoralea corylifolia seeds. Acts as a functional retinoid analogue by upregulating Type I, III, and IV collagen gene expression and inhibiting matrix metalloproteinases without structural retinoid receptor binding, phototoxicity, or retinoid dermatitis.
■ [3. Global 6-Jurisdiction Regulatory Status & Safety Limits (Layer 1 & Layer 2)]
  - Regional Summary: KR: NONE | EU: NONE | US: NONE | CN: ALLOWED | JP: NONE | ASEAN: NONE (CN IECIC (2025) Entry No. Unlisted (-))
  - No specific Annex prohibition or numeric restriction across the 6 major jurisdictions (Permitted under general GMP safety assessment).
  - Official Safety & Historical Use Concentration (Layer 2): CN_IECIC_2025 (cn_iecic_max, leave_on): Max 2.0% / CN_IECIC_2025 (cn_iecic_max, rinse_off): Max 1.0%
■ [4. Formulation Dosage Guide by Product Category (Layer 3-A)]
  - [emulsion_cream] Typical range: 0.5 ~ 1.0% (Median 0.75%, Ref: Sytheon Sytenol A Monograph & Dhaliwal et al. Br J Dermatol 2019 (PMID: 29947134)) — Photostable phyto-retinoid functional analogue stimulating Type I/III/IV collagen without retinoid irritation
  - [anhydrous_balm] Typical range: 0.5 ~ 2.0% (Median 1.0%, Ref: PubMed Bakuchiol Clinical Trials & CN IECIC) — Clean-beauty facial oil phyto-retinoid active
■ [5. Formulation Engineering, Stability & Incompatibility Matrix (Layer 3-B)]
  - Addition Phase: Oil Phase (< 75°C) or Cool-down Phase
  - Optimal pH Range: pH 4.5 ~ 6.5 | Max Process Temp: Max 75°C | Electrolyte Tolerance: HIGH
  - Incompatibility / Caution: Phenolic structure forms dark reddish-brown complexes with trace iron ions (Fe3+) or at alkaline pH (>7.0); always include 0.05~0.1% Sodium Phytate or Disodium EDTA and keep pH 5.0~6.0
  - Incompatibility / Caution: Must use ≥99% purified grade depleted of phototoxic psoralens (<100 ppm)
  - Synergy Pairings: RETINOL, SQUALANE, CAPRYLIC/CAPRIC TRIGLYCERIDE, SODIUM PHYTATE, TOCOPHEROL | Reference Trade Names: Sytenol® A (Sytheon)
■ [6. Peer-Reviewed Literature & Official Compendia Evidence]
  - PMID 36176207 (2022, J Cosmet Dermatol): Applications of bakuchiol in dermatology: Systematic review of the literature
  - PMID 38021404 (2023, F1000Res): Bakuchiol, a natural constituent and its pharmacological benefits
  - PMID 38564402 (2024, J Drugs Dermatol): Human Clinical Trials Using Topical Bakuchiol Formulations for the Treatment of Skin Disorders: A Systematic Review

## 6. Linked PubMed Literature
- [PMID: 36176207] Applications of bakuchiol in dermatology: Systematic review of the literature — *J Cosmet Dermatol* (2022)
- [PMID: 38021404] Bakuchiol, a natural constituent and its pharmacological benefits — *F1000Res* (2023)
- [PMID: 38564402] Human Clinical Trials Using Topical Bakuchiol Formulations for the Treatment of Skin Disorders: A Systematic Review — *J Drugs Dermatol* (2024)
- [PMID: 36748816] Therapeutic and Health Promoting Potential of Bakuchiol from Psoralea corylifolia: A Comprehensive Review — *Endocr Metab Immune Disord Drug Targets* (2023)
- [PMID: 29947134] Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing — *British Journal of Dermatology* (2019)
- [PMID: 24471735] Bakuchiol: a retinol-like functional compound that regulates skin collagen biogenesis — *International Journal of Cosmetic Science* (2014)
- [PMID: 42242599] Bakuchiol, a potentially toxic component in Fructus psoraleae, causes liver damage in vitro by affecting the homeostasis of the liver GABA signalling system. — *J Ethnopharmacol* (2026)
- [PMID: 41562471] A Randomized Controlled Trial of the Genistein Plus Bakuchiol and Vitamins (GEN(+)) Product for Male Facial Skin: Effects on Skin Appearance and Properties — *Skin Res Technol* (2026)
- [PMID: 41424674] Prospective, Randomized, Double-Blind Assessment of Supramolecular Bakuchiol and Terminalia Chebula Extract for Facial Photoaging in Chinese Sensitive Skin Population — *Health Sci Rep* (2025)
- [PMID: 40905519] Bioretinoids from microalgae: Boosting retinol performance and tolerability — *Int J Cosmet Sci* (2026)
- [PMID: 40724887] Comparison of Quantification Using UV-Vis, NMR, and HPLC Methods of Retinol-Like Bakuchiol Present in Cosmetic Products — *Int J Mol Sci* (2025)
- [PMID: 40562285] Cutaneous delivery and biodistribution of a lipophilic natural product - bakuchiol: Comparing nanocarrier performance — *Int J Pharm* (2025)
- [PMID: 41772644] Bakuchiol-loaded amphiphilic polymeric nanoparticles: enhancing stability and multifunctionality through encapsulation. — *J Biol Eng* (2026)
- [PMID: ] PubChem Compound Summary: Bakuchiol — *PubChem Compound Database* (2026)
- [PMID: 41365395] Effects of nutritive and non-nutritive sweeteners on acne vulgaris: A systematic review — *Fitoterapia* (2026)
- [PMID: 40327583] INDIVIDUAL ARTICLE: A Scientific Approach to Defining, Evaluating, and Treating Pre-Aging With a Cosmetic Regimen Containing a Novel Cosmetic Peptide, Acetyl Dipeptide-31 Amide (AP31) — *J Drugs Dermatol* (2025)