# CAPRYLYL GLYCOL (caprylyl-glycol) — Global Cosmetic Regulatory & Formulation Monograph

- **Canonical URL**: https://www.inciname.com/en/ingredients/caprylyl-glycol
- **Standard INCI**: `CAPRYLYL GLYCOL`
- **KR MFDS Standard Name**: `카프릴릴글라이콜`
- **CAS No.**: `1117-86-8`
- **EC / EINECS No.**: `214-254-7`
- **Origin**: `synthetic`
- **Functions**: 데오도란트, 모발컨디셔닝제, 피부컨디셔닝제, 에모리엔트
- **Molecular Formula / MW**: `—` (— g/mol)

## 1. 7-Track Official Regulatory Label Names
| Track | Official Label Nomenclature |
| :--- | :--- |
| KR (MFDS Standard) | 카프릴릴글라이콜 |
| KR (Former Names) | — |
| EU (CosIng 1223/2009) | CAPRYLYL GLYCOL |
| US (PCPC / MoCRA INCI) | CAPRYLYL GLYCOL |
| US (FDA OTC Monograph) | — |
| CN (NMPA IECIC) | 辛甘醇 |
| JP (JCIA / MHLW QD) | CAPRYLYL GLYCOL  |

## 2. Layer 1 — Global 6-Region Statutory Summary
- **KR (MFDS)**: `none`
- **EU (1223/2009)**: `none`
- **US (FDA/MoCRA)**: `none`
- **CN (NMPA IECIC)**: `allowed` (Entry: `7160`)
- **JP (MHLW)**: `none`
- **ASEAN (ACD)**: `none`



## 3. Layer 2 — Toxicological & Historical Safe Use Concentrations
- **reported_use** (baby): 0.6~0.6% — 116_tent_capryl.pdf (null)
- **reported_use** (bath): 0.0004~1% — 116_tent_capryl.pdf (null)
- **reported_use** (eye): 0.3~5% — 116_tent_capryl.pdf (null)
- **reported_use** (total): 0.00003~5% — 116_tent_capryl.pdf (null)
- **reported_use** (powder): 0.3~0.3% — 116_tent_capryl.pdf (null)
- **reported_use** (hair): 0.0002~2% — 116_tent_capryl.pdf (null)
- **reported_use** (hair_dye): 0.002~5% — 116_tent_capryl.pdf (null)
- **reported_use** (dermal): 0.0003~5% — 116_tent_capryl.pdf (null)
- **reported_use** (deodorant): 0.03~2% — 119_final_12glc.pdf (null)
- **reported_use** (nail): 0.0004~0.5% — 119_final_12glc.pdf (null)
- **reported_use** (leave_on): 0.00003~5% — 119_final_12glc.pdf (null)
- **reported_use** (rinse_off): 0.0004~2% — 119_final_12glc.pdf (null)
- **cn_iecic_max** (leave_on): ≤ 5% — NMPA IECIC (2025) Entry 07398 (2025)
- **cn_iecic_max** (rinse_off): ≤ 5% — NMPA IECIC (2025) Entry 07398 (2025)

## 4. Layer 3 — Formulation Quartiles & Compatibility
- **Optimal pH Window**: 4 – 8
- **Max Process Temp**: ≤ 50°C
- **Synergy Pairings**: GLYCERIN, CAPRYLIC/CAPRIC TRIGLYCERIDE, TOCOPHEROL
- **Incompatibilities**: Verify phase compatibility under extreme pH or high electrolyte loads

## 5. Academic Monograph
■ [1. Chemical Identity & International Labeling Nomenclature]
  - INCI Name: CAPRYLYL GLYCOL | CAS No.: 1117-86-8 | EC No.: 214-254-7
  - Origin: SYNTHETIC | Functions: , , , 
  - Physicochemical Profile: Formula      | MW /(Polymer/Complex) | /   | Ionic Nature: non-ionic | CosIng/MFDS 
  - Official Regional Label Names: US [CAPRYLYL GLYCOL] · EU [CAPRYLYL GLYCOL] · CN [辛甘醇] · JP [-] · JP Quasi-Drug [-]
■ [2. Dermatological Mechanism of Action & Functional Role]
  - Caprylyl Glycol is the diol that conforms to the formula Classified under origin 'synthetic', it acts within the cosmetic vehicle or stratum corneum to deliver , , ,  performance and structural formulation stability.
■ [3. Global 6-Jurisdiction Regulatory Status & Safety Limits (Layer 1 & Layer 2)]
  - Regional Summary: KR: NONE | EU: NONE | US: NONE | CN: ALLOWED | JP: NONE | ASEAN: NONE (CN IECIC (2025) Entry No. 7160 (辛甘醇))
  - No specific Annex prohibition or numeric restriction across the 6 major jurisdictions (Permitted under general GMP safety assessment).
  - Official Safety & Historical Use Concentration (Layer 2): cir (reported_use, baby): 0.6~0.6% / cir (reported_use, bath): 0.0004~1% / cir (reported_use, eye): 0.3~5%
■ [4. Formulation Dosage Guide by Product Category (Layer 3-A)]
  - [aqueous_serum] Typical range: 0.5 ~ 3.5% (Median 3.0%, Ref: Global Starter Formulation Library Statistical Distribution (n=6, EVONIK 4 · GRANT 1 · SEPPIC 1)) — Aqueous serum, toner & hydrogel matrix formulation component
  - [cleanser_rinse] Typical range: 0.5 ~ 1.2% (Median 1.0%, Ref: Global Starter Formulation Library Statistical Distribution (n=5, SEPPIC 3 · EVONIK 2)) — Rinse-off cleanser & surfactant system modifier
  - [emulsion_cream] Typical range: 0.1 ~ 4.0% (Median 0.5%, Ref: Global Starter Formulation Library Statistical Distribution (n=23, EVONIK 13 · SEPPIC 10)) — Emulsion cream & lotion structural / conditioning agent
■ [5. Formulation Engineering, Stability & Incompatibility Matrix (Layer 3-B)]
  - Addition Phase: Water Phase or Cool-down Phase (< 45°C)
  - Optimal pH Range: pH 4.0 ~ 8.0 | Max Process Temp: Max 50°C | Electrolyte Tolerance: MEDIUM
  - Incompatibility / Caution: Verify phase compatibility under extreme pH or high electrolyte loads
  - Synergy Pairings: GLYCERIN, CAPRYLIC/CAPRIC TRIGLYCERIDE, TOCOPHEROL | Reference Trade Names: CAPRYLYL GLYCOL
■ [6. Peer-Reviewed Literature & Official Compendia Evidence]
  - PMID 40855841 (2025, Contact Dermatitis): Caprylyl Glycol, a Trending and Highly Relevant Sensitiser in Cosmetics That Needs to be Patch Tested Separately
  - PMID 39153997 (2024, Sci Rep): Deciphering trends in replacing preservatives in cosmetics intended for infants and sensitive population
  - PMID 34586708 (2022, J Appl Microbiol): Real-time qPCR to evaluate bacterial contamination of cosmetic cream and the efficiency of protective ingredients

## 6. Linked PubMed Literature
- [PMID: 40855841] Caprylyl Glycol, a Trending and Highly Relevant Sensitiser in Cosmetics That Needs to be Patch Tested Separately — *Contact Dermatitis* (2025)
- [PMID: 39153997] Deciphering trends in replacing preservatives in cosmetics intended for infants and sensitive population — *Sci Rep* (2024)
- [PMID: 34586708] Real-time qPCR to evaluate bacterial contamination of cosmetic cream and the efficiency of protective ingredients — *J Appl Microbiol* (2022)
- [PMID: 33624850] Integrated approaches to testing and assessment as a tool for the hazard assessment and risk characterization of cosmetic preservatives — *J Appl Toxicol* (2021)
- [PMID: 32468581] Allergic contact dermatitis to caprylyl glycol: A novel "para-preservative" allergen — *Contact Dermatitis* (2020)
- [PMID: 31026059] Contact urticaria following the use of a cosmetic containing caprylyl glycol: A case report — *Contact Dermatitis* (2019)
- [PMID: 27154641] Determination of alternative preservatives in cosmetic products by chromophoric derivatization followed by vortex-assisted liquid-liquid semimicroextraction and liquid chromatography — *Talanta* (2016)
- [PMID: 26940643] A new alternative to cosmetics preservation and the effect of the particle size of the emulsion droplets on preservation efficacy — *Int J Cosmet Sci* (2016)
- [PMID: 23064773] Safety assessment of 1,2-glycols as used in cosmetics — *Int J Toxicol* (2012)
- [PMID: 24716405] Nanosuspensions of hesperetin: preparation and characterization — *Pharmazie* (2014)
- [PMID: 38330048] MALDI-TOF imaging analysis of benzalkonium chloride penetration in ex vivo human skin — *PLoS One* (2024)
- [PMID: 22312699] Resveratrol nanosuspensions: interaction of preservatives with nanocrystal production — *Pharmazie* (2011)