# CARRAGEENAN (carrageenan) — Global Cosmetic Regulatory & Formulation Monograph - **Canonical URL**: https://www.inciname.com/en/ingredients/carrageenan - **Standard INCI**: `CARRAGEENAN` - **KR MFDS Standard Name**: `카라기난` - **CAS No.**: `9000-07-1` - **EC / EINECS No.**: `232-524-2` - **Origin**: `plant` - **Functions**: 피부컨디셔닝제 - **Molecular Formula / MW**: `—` (— g/mol) ## 1. 7-Track Official Regulatory Label Names | Track | Official Label Nomenclature | | :--- | :--- | | KR (MFDS Standard) | 카라기난 | | KR (Former Names) | — | | EU (CosIng 1223/2009) | CARRAGEENAN | | US (PCPC / MoCRA INCI) | CARRAGEENAN | | US (FDA OTC Monograph) | — | | CN (NMPA IECIC) | — | | JP (JCIA / MHLW QD) | CARRAGEENAN | ## 2. Layer 1 — Global 6-Region Statutory Summary - **KR (MFDS)**: `none` - **EU (1223/2009)**: `none` - **US (FDA/MoCRA)**: `none` - **CN (NMPA IECIC)**: `none` (Entry: `—`) - **JP (MHLW)**: `none` - **ASEAN (ACD)**: `none` ## 3. Layer 2 — Toxicological & Historical Safe Use Concentrations - Listed within general cosmetic GMP safety thresholds. ## 4. Layer 3 — Formulation Quartiles & Compatibility - **Optimal pH Window**: 4 – 8 - **Max Process Temp**: ≤ 50°C - **Synergy Pairings**: GLYCERIN, CAPRYLIC/CAPRIC TRIGLYCERIDE, TOCOPHEROL - **Incompatibilities**: Verify phase compatibility under extreme pH or high electrolyte loads ## 5. Academic Monograph ■ [1. Chemical Identity & International Labeling Nomenclature] - INCI Name: CARRAGEENAN | CAS No.: 9000-07-1 | EC No.: 232-524-2 - Origin: PLANT | Functions: SKIN CONDITIONING - Physicochemical Profile: Formula | MW /(Polymer/Complex) | / | Ionic Nature: non-ionic | CosIng/MFDS - Official Regional Label Names: US [CARRAGEENAN] · EU [CARRAGEENAN] · CN [-] · JP [-] · JP Quasi-Drug [-] ■ [2. Dermatological Mechanism of Action & Functional Role] - Carrageenan is the plant material obtained from various members of the Gigartinaceae or Solieriaceae families of the red seaweed, Rodophyceae. Classified under origin 'plant', it acts within the cosmetic vehicle or stratum corneum to deliver SKIN CONDITIONING performance and structural formulation stability. ■ [3. Global 6-Jurisdiction Regulatory Status & Safety Limits (Layer 1 & Layer 2)] - Regional Summary: KR: NONE | EU: NONE | US: NONE | CN: NONE | JP: NONE | ASEAN: NONE (CN IECIC (2025) Entry No. Unlisted (-)) - No specific Annex prohibition or numeric restriction across the 6 major jurisdictions (Permitted under general GMP safety assessment). - Official Safety & Historical Use Concentration (Layer 2): Quantum satis (QS) within standard cosmetic safety margins ■ [4. Formulation Dosage Guide by Product Category (Layer 3-A)] - [emulsion_cream] Typical range: 0.1 ~ 0.2% (Median 0.1%, Ref: Global Starter Formulation Library Statistical Distribution (n=16, EVONIK 16)) — Emulsion cream & lotion structural / conditioning agent ■ [5. Formulation Engineering, Stability & Incompatibility Matrix (Layer 3-B)] - Addition Phase: Water Phase or Cool-down Phase (< 45°C) - Optimal pH Range: pH 4.0 ~ 8.0 | Max Process Temp: Max 50°C | Electrolyte Tolerance: MEDIUM - Incompatibility / Caution: Verify phase compatibility under extreme pH or high electrolyte loads - Synergy Pairings: GLYCERIN, CAPRYLIC/CAPRIC TRIGLYCERIDE, TOCOPHEROL | Reference Trade Names: CARRAGEENAN ■ [6. Peer-Reviewed Literature & Official Compendia Evidence] - PMID 42267531 (2026, J Am Chem Soc): Total Synthesis of Conjugation-Ready Sulfated Red Algae Carrageenan Oligosaccharides for Sensing Applications - PMID 42242600 (2026, J Ethnopharmacol): Comprehensive phytochemical and pharmacological investigation of Cynoglossum clandestinum desf. ethanolic leaf extract: - PMID 42228581 (2026, ACS Sens): Imperceptible Hydrogel Electronic Skin for Early Intervention in Neck Pain: Multimodal Wireless Monitoring of Cervical K ## 6. Linked PubMed Literature - [PMID: 42267531] Total Synthesis of Conjugation-Ready Sulfated Red Algae Carrageenan Oligosaccharides for Sensing Applications — *J Am Chem Soc* (2026) - [PMID: 42242600] Comprehensive phytochemical and pharmacological investigation of Cynoglossum clandestinum desf. ethanolic leaf extract: In vitro, In vivo, and In silico assessment of antioxidant, anti-inflammatory, and antidepressant properties — *J Ethnopharmacol* (2026) - [PMID: 42228581] Imperceptible Hydrogel Electronic Skin for Early Intervention in Neck Pain: Multimodal Wireless Monitoring of Cervical Kinematics and Muscle Fatigue — *ACS Sens* (2026) - [PMID: 42167469] Biomarker-based assessment of somatostatin-6 immunomodulation in gilthead seabream: From serum proteins to skin mucus enzymes — *Dev Comp Immunol* (2026) - [PMID: 42133922] Mixture design-modelling and optimization of ketoprofen solid lipid nanoparticles for augmented anti-inflammatory activity following pharmacodynamic evaluation in rats — *Pharm Dev Technol* (2026) - [PMID: 42075018] Synergistic Virus Neutralizing Activities of European Black Elderberry Fruit Extract and Iota-Carrageenan Against SARS-CoV-2, Influenza A Virus and Respiratory Syncytial Virus — *Nutrients* (2026) - [PMID: 42066871] λ-carrageenan-induced inflammation modulates transposable element expression in skin and brain of gilthead seabream (Sparus aurata) — *Fish Shellfish Immunol* (2026) - [PMID: 42041520] Adhesive κ-Carrageenan Hydrogels by Polyphenol Intervention — *Biomimetics (Basel)* (2026) - [PMID: 42295701] Transdermal delivery and anti-inflammatory efficacy of Mitragyna speciosa extract transdermal patch for local inflammation management: in vitro, ex vivo, and in vivo investigations — *Drug Deliv Transl Res* (2026) - [PMID: 42281344] Exploring the role of alpha-tocopherol in pain and inflammation: interplay with TRPV1, PKA, and PKC pathways — *Korean J Pain* (2026) - [PMID: 42123888] Exploring the Antioxidant, Anti-Inflammatory and Skin-Enzyme Inhibitory Activities of Balkan Ethnomedicinal Herbs Through In Vitro and In Vivo Screening — *Molecules* (2026) - [PMID: 42028126] Neuropharmacological, Analgesic, and Anti-Inflammatory Activities of Pothos scandens Acetone Extract With GC-MS-Based Phytochemical Profiling — *Biochem Res Int* (2026)