# CENTELLA ASIATICA EXTRACT (centella-asiatica-extract) — Global Cosmetic Regulatory & Formulation Monograph

- **Canonical URL**: https://www.inciname.com/en/ingredients/centella-asiatica-extract
- **Standard INCI**: `CENTELLA ASIATICA EXTRACT`
- **KR MFDS Standard Name**: `병풀추출물`
- **CAS No.**: `84696-21-9`
- **EC / EINECS No.**: `283-640-5`
- **Origin**: `plant`
- **Functions**: 세정제, 피부컨디셔닝제, 평활제, 토닉, 진정제
- **Molecular Formula / MW**: `—` (— g/mol)

## 1. 7-Track Official Regulatory Label Names
| Track | Official Label Nomenclature |
| :--- | :--- |
| KR (MFDS Standard) | 병풀추출물 |
| KR (Former Names) | — |
| EU (CosIng 1223/2009) | CENTELLA ASIATICA EXTRACT |
| US (PCPC / MoCRA INCI) | CENTELLA ASIATICA EXTRACT |
| US (FDA OTC Monograph) | — |
| CN (NMPA IECIC) | 积雪草(CENTELLA ASIATICA)提取物 |
| JP (JCIA / MHLW QD) | ツボクサエキス (QD: ツボクサエキス) |

## 2. Layer 1 — Global 6-Region Statutory Summary
- **KR (MFDS)**: `none`
- **EU (1223/2009)**: `none`
- **US (FDA/MoCRA)**: `none`
- **CN (NMPA IECIC)**: `allowed` (Entry: `3171`)
- **JP (MHLW)**: `none`
- **ASEAN (ACD)**: `none`



## 3. Layer 2 — Toxicological & Historical Safe Use Concentrations
- **cn_iecic_max** (leave_on): ≤ 10.5% — NMPA IECIC (2025) Entry 03212 (2025)
- **cn_iecic_max** (rinse_off): ≤ 5% — NMPA IECIC (2025) Entry 03212 (2025)

## 4. Layer 3 — Formulation Quartiles & Compatibility
- **Optimal pH Window**: 4.5 – 7.5
- **Max Process Temp**: ≤ 70°C
- **Synergy Pairings**: —
- **Incompatibilities**: —

## 5. Academic Monograph
Centella asiatica extract is a traditional medicinal plant containing major bioactive compounds including asiaticoside, madecassoside, asiatic acid, and madecassic acid.
It exhibits antioxidant, anti-inflammatory, regenerative, neuroprotective, and cytoprotective activities, and modulates signaling pathways involved in oxidative stress, inflammation, apoptosis, extracellular matrix remodeling, and cellular survival (NF-κB, PI3K/Akt/mTOR, MAPK, Nrf2/HO-1, TGF-β/Smad).
During wound healing, it stimulates collagen I, Fibroblast Growth Factor (FGF), and Vascular Endothelial Growth Factor (VEGF) production to enhance angiogenesis and promote wound contraction, granulation tissue formation, and re-epithelialization.
It exerts anti-inflammatory effects by reducing Interleukin-1β (IL-1β), Interleukin-6 (IL-6), Tumor Necrosis Factor α (TNF-α), prostaglandin E2 (PGE2), cyclooxygenase-2 (COX-2), and lipoxygenase (LOX) activity.
It demonstrates positive effects on skin aging and wound healing through attenuation of cellular senescence, improvement of mitochondrial function, enhanced collagen synthesis, and regulation of cytokine production.
Oral supplementation reduces wrinkle depth by 11.1%, maximum wrinkle depth by 13.3%, surface roughness by 10.4%, and decreases transepidermal water loss to improve skin barrier function.
It protects human gingival fibroblast viability and migration, maintains antimicrobial activity, modulates macrophage immune responses, and enhances vascular density and branching complexity.
In diabetic wound models, it decreases inflammatory cell infiltration and increases fibroblast density, angiogenesis, and epithelialization, while reducing TNF-α and increasing FGF-2, EGF, VEGF, and IGF-1 expression.

## 6. Linked PubMed Literature
- [PMID: 24399761] Centella asiatica in dermatology: an overview — *Phytother Res* (2014)
- [PMID: 24278045] Centella asiatica in cosmetology — *Postepy Dermatol Alergol* (2013)
- [PMID: 35328954] A Systematic Review of the Effect of Centella asiatica on Wound Healing — *Int J Environ Res Public Health* (2022)
- [PMID: 34845411] Pharmacological Effects of Centella asiatica on Skin Diseases: Evidence and Possible Mechanisms — *Evid Based Complement Alternat Med* (2021)
- [PMID: 36837896] Centella asiatica and Its Metabolite Asiatic Acid: Wound Healing Effects and Therapeutic Potential — *Metabolites* (2023)
- [PMID: 39458583] Topical Application of Centella asiatica in Wound Healing: Recent Insights into Mechanisms and Clinical Efficacy — *Pharmaceutics* (2024)
- [PMID: 42280293] Geroprotective Potential of Centella asiatica: Modulation of Cellular Aging. — *Nutrients* (2026)
- [PMID: 42196964] A Randomized, Double-Blind, Placebo-Controlled Trial Assessing the Effects of Oral Centella asiatica Extract on Skin Aging-Related Parameters in Middle-Aged Korean Women. — *Nutrients* (2026)
- [PMID: 41950551] Standardized Centella asiatica extract (ECa 233) mitigates chlorhexidine-induced cytotoxicity and promotes oral wound repair via immunomodulation and angiogenesis — *Arch Oral Biol* (2026)
- [PMID: 41934524] Effects of Centella asiatica extract on burn wound healing in streptozotocin-induced diabetic rats: a pathological and molecular evaluation — *J Mol Histol* (2026)
- [PMID: 41680114] Thermally Stable Nanoarchitectonics of Bicellar Nanocarriers for Superior Transdermal Delivery of Centella asiatica Extracts — *ACS Appl Mater Interfaces* (2026)
- [PMID: 41625967] Herbal Cocktail Hydrogel Film (Garcinia mangostana, Centella asiatica, and Chromolaena odorata Extracts): A Novel Wound Dressing Approach — *Int J Biomater* (2026)
- [PMID: 41574389] Enhancing Wound Healing with a Novel Alginate/Eggshell Membrane-Based Hydrogel Enriched with Red Ginseng Roots and Centella Asiatica — *Skin Res Technol* (2026)
- [PMID: 41569283] Posidonia oceanica extract in wound healing: exploring its potential and comparison with conventional topical therapies — *Cutan Ocul Toxicol* (2026)
- [PMID: 41516082] Oral Centella asiatica Extract Attenuates UVB-Induced Skin Photoaging via Antioxidant, Anti-Inflammatory, and Extracellular Matrix-Preserving Effects in Hairless Mice — *Int J Mol Sci* (2025)
- [PMID: 41025315] Transfersomal delivery of Centella asiatica promotes efficient excision wound healing in rats — *Drug Deliv* (2025)
- [PMID: 41011143] Anti-Inflammatory and Antioxidant Effects of Topical Formulations Containing Plant Extracts, Methylsulfonylmethane, and Peptiskin(®) in In Vitro Models of Arthritis — *Pharmaceuticals (Basel)* (2025)
- [PMID: 41009551] In Vitro Characterization of Centella asiatica Extracellular Vesicles and Their Skin Repair Effects in a UVB-Irradiated Mouse Model — *Int J Mol Sci* (2025)