# FRAGRANCE (fragrance) — Global Cosmetic Regulatory & Formulation Monograph

- **Canonical URL**: https://www.inciname.com/en/ingredients/fragrance
- **Standard INCI**: `FRAGRANCE`
- **KR MFDS Standard Name**: `향료`
- **CAS No.**: `N/A`
- **EC / EINECS No.**: `N/A`
- **Origin**: `synthetic`
- **Functions**: 피부컨디셔닝제
- **Molecular Formula / MW**: `—` (— g/mol)

## 1. 7-Track Official Regulatory Label Names
| Track | Official Label Nomenclature |
| :--- | :--- |
| KR (MFDS Standard) | 향료 |
| KR (Former Names) | — |
| EU (CosIng 1223/2009) | PARFUM |
| US (PCPC / MoCRA INCI) | FRAGRANCE |
| US (FDA OTC Monograph) | — |
| CN (NMPA IECIC) | (日用)香精 |
| JP (JCIA / MHLW QD) | FRAGRANCE  |

## 2. Layer 1 — Global 6-Region Statutory Summary
- **KR (MFDS)**: `none`
- **EU (1223/2009)**: `none`
- **US (FDA/MoCRA)**: `none`
- **CN (NMPA IECIC)**: `allowed` (Entry: `8782`)
- **JP (MHLW)**: `none`
- **ASEAN (ACD)**: `none`



## 3. Layer 2 — Toxicological & Historical Safe Use Concentrations
- Listed within general cosmetic GMP safety thresholds.

## 4. Layer 3 — Formulation Quartiles & Compatibility
- **Optimal pH Window**: 4 – 8
- **Max Process Temp**: ≤ 50°C
- **Synergy Pairings**: GLYCERIN, CAPRYLIC/CAPRIC TRIGLYCERIDE, TOCOPHEROL
- **Incompatibilities**: Verify phase compatibility under extreme pH or high electrolyte loads

## 5. Academic Monograph
■ [1. Chemical Identity & International Labeling Nomenclature]
  - INCI Name: FRAGRANCE | CAS No.: N/A | EC No.: N/A
  - Origin: SYNTHETIC | Functions: SKIN CONDITIONING
  - Physicochemical Profile: Formula      | MW /(Polymer/Complex) | /   | Ionic Nature: non-ionic | CosIng/MFDS 
  - Official Regional Label Names: US [FRAGRANCE] · EU [PARFUM] · CN [(日用)香精] · JP [-] · JP Quasi-Drug [-]
■ [2. Dermatological Mechanism of Action & Functional Role]
  - FRAGRANCE functions primarily as SKIN CONDITIONING in dermatological and cosmetic formulations. Classified under origin 'synthetic', it acts within the cosmetic vehicle or stratum corneum to deliver SKIN CONDITIONING performance and structural formulation stability.
■ [3. Global 6-Jurisdiction Regulatory Status & Safety Limits (Layer 1 & Layer 2)]
  - Regional Summary: KR: NONE | EU: NONE | US: NONE | CN: ALLOWED | JP: NONE | ASEAN: NONE (CN IECIC (2025) Entry No. 8782 ((日用)香精))
  - No specific Annex prohibition or numeric restriction across the 6 major jurisdictions (Permitted under general GMP safety assessment).
  - Official Safety & Historical Use Concentration (Layer 2): Quantum satis (QS) within standard cosmetic safety margins
■ [4. Formulation Dosage Guide by Product Category (Layer 3-A)]
  - [anhydrous_balm] Typical range: 0.05 ~ 0.5% (Median 0.25%, Ref: Global Starter Formulation Library Statistical Distribution (n=16, SEPPIC 14 · GRANT 2)) — Anhydrous balm, oil & stick structural emollient
  - [aqueous_serum] Typical range: 0.01 ~ 14.0% (Median 0.1%, Ref: Global Starter Formulation Library Statistical Distribution (n=61, SEPPIC 55 · GRANT 6)) — Aqueous serum, toner & hydrogel matrix formulation component
  - [cleanser_rinse] Typical range: 0.05 ~ 1.0% (Median 0.3%, Ref: Global Starter Formulation Library Statistical Distribution (n=51, SEPPIC 40 · GRANT 11)) — Rinse-off cleanser & surfactant system modifier
■ [5. Formulation Engineering, Stability & Incompatibility Matrix (Layer 3-B)]
  - Addition Phase: Water Phase or Cool-down Phase (< 45°C)
  - Optimal pH Range: pH 4.0 ~ 8.0 | Max Process Temp: Max 50°C | Electrolyte Tolerance: MEDIUM
  - Incompatibility / Caution: Verify phase compatibility under extreme pH or high electrolyte loads
  - Synergy Pairings: GLYCERIN, CAPRYLIC/CAPRIC TRIGLYCERIDE, TOCOPHEROL | Reference Trade Names: FRAGRANCE
■ [6. Peer-Reviewed Literature & Official Compendia Evidence]
  - PMID 42298598 (2026, J Orthop Surg Res): Hybrid deep learning ensemble model for detecting small to medium rotator cuff tears from shoulder radiographs
  - PMID 42280252 (2026, Molecules): Climate Zone of Geographical Origin Associations with Essential Oil Composition, Yield, and Chemotype Distribution in Co
  - PMID 42264933 (2026, Drug Dev Ind Pharm): Medium-Chain Fatty Acid-Enabled Nanostructured Lipid Carriers for Improved β-carotene Biopharmaceutical Properties and A

## 6. Linked PubMed Literature
- [PMID: 42298598] Hybrid deep learning ensemble model for detecting small to medium rotator cuff tears from shoulder radiographs — *J Orthop Surg Res* (2026)
- [PMID: 42280252] Climate Zone of Geographical Origin Associations with Essential Oil Composition, Yield, and Chemotype Distribution in Coriandrum sativum L.: A Multivariate Analysis of 48 Global Accessions — *Molecules* (2026)
- [PMID: 42264933] Medium-Chain Fatty Acid-Enabled Nanostructured Lipid Carriers for Improved β-carotene Biopharmaceutical Properties and Antioxidant Efficacy — *Drug Dev Ind Pharm* (2026)
- [PMID: 42255269] Black bean protein isolate-gum Arabic coacervated citronellal microcapsules: Preparation, characterization, antibacterial activities, and application in strawberry preservation — *Food Chem X* (2026)
- [PMID: 42248361] Short-term Clinical and Economic Outcomes Associated with Vocal Fold Paralysis in Adults Undergoing Thyroidectomy: Analysis of the National Readmissions Database, 2016-2020 — *Endocr Pract* (2026)
- [PMID: 42242012] A Longitudinal Study of Antimicrobial Resistance in Oral Bacterial Isolates From Periodontitis Patients in Taiwan — *Int Dent J* (2026)
- [PMID: 42240731] Chemicals of Concern in Chemical Hair Straightening Products: A Scoping Review — *Curr Environ Health Rep* (2026)
- [PMID: 42231174] Chemical profiling and chemotypic diversity of basil (Ocimum basilicum L.) genotypes: a large-scale evaluation of bioactive compounds and antioxidant capacity — *BMC Plant Biol* (2026)
- [PMID: 42223633] How Touch Triggers Mechanotransduction in Cutaneous Mechanoreceptors — *Results Probl Cell Differ* (2026)
- [PMID: 42221231] Flavor omics approach of dried Lyophyllum decastes mushroom using GC-IMS, GC-O-MS, E-nose, E-tongue, and multiple factor analysis — *Food Chem X* (2026)
- [PMID: 42219126] De novo gamma-decalactone bioproduction from Ashbya gossypii: Process design, techno-economic evaluation and environmental assessment — *Bioresour Technol* (2026)
- [PMID: 42214141] In situ pH-responsive deep eutectic solvent for homogeneous liquid-liquid extraction of preservatives and an antioxidant from aqueous and oily matrices — *J Chromatogr A* (2026)