# HYDROLYZED HYALURONIC ACID (hydrolyzed-hyaluronic-acid) — Global Cosmetic Regulatory & Formulation Monograph

- **Canonical URL**: https://www.inciname.com/en/ingredients/hydrolyzed-hyaluronic-acid
- **Standard INCI**: `HYDROLYZED HYALURONIC ACID`
- **KR MFDS Standard Name**: `하이드롤라이즈드하이알루로닉애씨드`
- **CAS No.**: `N/A`
- **EC / EINECS No.**: `N/A`
- **Origin**: `synthetic`
- **Functions**: 모발컨디셔닝제, 보습제, 피부컨디셔닝제
- **Molecular Formula / MW**: `—` (— g/mol)

## 1. 7-Track Official Regulatory Label Names
| Track | Official Label Nomenclature |
| :--- | :--- |
| KR (MFDS Standard) | 하이드롤라이즈드하이알루로닉애씨드 |
| KR (Former Names) | — |
| EU (CosIng 1223/2009) | HYDROLYZED HYALURONIC ACID |
| US (PCPC / MoCRA INCI) | HYDROLYZED HYALURONIC ACID |
| US (FDA OTC Monograph) | — |
| CN (NMPA IECIC) | 水解透明质酸 |
| JP (JCIA / MHLW QD) | 加水分解ヒアルロン酸 (QD: 加水分解ヒアルロン酸) |

## 2. Layer 1 — Global 6-Region Statutory Summary
- **KR (MFDS)**: `none`
- **EU (1223/2009)**: `none`
- **US (FDA/MoCRA)**: `none`
- **CN (NMPA IECIC)**: `allowed` (Entry: `6353`)
- **JP (MHLW)**: `none`
- **ASEAN (ACD)**: `none`



## 3. Layer 2 — Toxicological & Historical Safe Use Concentrations
- **cn_iecic_max** (leave_on): ≤ 2% — NMPA IECIC (2025) Entry 06154 (2025)
- **cn_iecic_max** (rinse_off): ≤ 1.5% — NMPA IECIC (2025) Entry 06154 (2025)

## 4. Layer 3 — Formulation Quartiles & Compatibility
- **Optimal pH Window**: 4 – 8
- **Max Process Temp**: ≤ 50°C
- **Synergy Pairings**: GLYCERIN, CAPRYLIC/CAPRIC TRIGLYCERIDE, TOCOPHEROL
- **Incompatibilities**: Verify phase compatibility under extreme pH or high electrolyte loads

## 5. Academic Monograph
■ [1. Chemical Identity & International Labeling Nomenclature]
  - INCI Name: HYDROLYZED HYALURONIC ACID | CAS No.: N/A | EC No.: N/A
  - Origin: SYNTHETIC | Functions: , , 
  - Physicochemical Profile: Formula      | MW /(Polymer/Complex) | /   | Ionic Nature: non-ionic | CosIng/MFDS 
  - Official Regional Label Names: US [HYDROLYZED HYALURONIC ACID] · EU [HYDROLYZED HYALURONIC ACID] · CN [水解透明质酸] · JP [加水分解ヒアルロン酸] · JP Quasi-Drug [加水分解ヒアルロン酸]
■ [2. Dermatological Mechanism of Action & Functional Role]
  - Hydrolyzed Hyaluronic Acid is the hydrolysate of Hyaluronic Acid derived by acid, enzyme or other method of hydrolysis Classified under origin 'synthetic', it acts within the cosmetic vehicle or stratum corneum to deliver , ,  performance and structural formulation stability.
■ [3. Global 6-Jurisdiction Regulatory Status & Safety Limits (Layer 1 & Layer 2)]
  - Regional Summary: KR: NONE | EU: NONE | US: NONE | CN: ALLOWED | JP: NONE | ASEAN: NONE (CN IECIC (2025) Entry No. 6353 (水解透明质酸))
  - No specific Annex prohibition or numeric restriction across the 6 major jurisdictions (Permitted under general GMP safety assessment).
  - Official Safety & Historical Use Concentration (Layer 2): CN_IECIC_2025 (cn_iecic_max, leave_on): Max 2.0% / CN_IECIC_2025 (cn_iecic_max, rinse_off): Max 1.5%
■ [4. Formulation Dosage Guide by Product Category (Layer 3-A)]
  - [aqueous_serum] Typical range: 0.05 ~ 0.1% (Median 0.1%, Ref: Global Starter Formulation Library Statistical Distribution (n=6, EVONIK 6)) — Aqueous serum, toner & hydrogel matrix formulation component
  - [emulsion_cream] Typical range: 0.03 ~ 0.5% (Median 0.1%, Ref: Global Starter Formulation Library Statistical Distribution (n=17, EVONIK 17)) — Emulsion cream & lotion structural / conditioning agent
■ [5. Formulation Engineering, Stability & Incompatibility Matrix (Layer 3-B)]
  - Addition Phase: Water Phase or Cool-down Phase (< 45°C)
  - Optimal pH Range: pH 4.0 ~ 8.0 | Max Process Temp: Max 50°C | Electrolyte Tolerance: MEDIUM
  - Incompatibility / Caution: Verify phase compatibility under extreme pH or high electrolyte loads
  - Synergy Pairings: GLYCERIN, CAPRYLIC/CAPRIC TRIGLYCERIDE, TOCOPHEROL | Reference Trade Names: HYDROLYZED HYALURONIC ACID
■ [6. Peer-Reviewed Literature & Official Compendia Evidence]
  - PMID 36547309 (2022, Gels): Fabrication of High-Resolution Fine Microneedles Derived from Hydrolyzed Hyaluronic Acid Gels in Vacuum Environment Impr
  - PMID 31376454 (2019, Int J Biol Macromol): Various methods to combine hyaluronic acid and antimicrobial peptides coatings and evaluation of their antibacterial beh
  - PMID 13076197 (1953, Science): Inactivation of vaccinia virus by a diffusible component from hydrolyzed hyaluronic acid

## 6. Linked PubMed Literature
- [PMID: 36547309] Fabrication of High-Resolution Fine Microneedles Derived from Hydrolyzed Hyaluronic Acid Gels in Vacuum Environment Imprinting Using Water Permeable Mold — *Gels* (2022)
- [PMID: 31376454] Various methods to combine hyaluronic acid and antimicrobial peptides coatings and evaluation of their antibacterial behaviour — *Int J Biol Macromol* (2019)
- [PMID: 13076197] Inactivation of vaccinia virus by a diffusible component from hydrolyzed hyaluronic acid — *Science* (1953)