# HYDROXYACETOPHENONE (hydroxyacetophenone) — Global Cosmetic Regulatory & Formulation Monograph

- **Canonical URL**: https://www.inciname.com/en/ingredients/hydroxyacetophenone
- **Standard INCI**: `HYDROXYACETOPHENONE`
- **KR MFDS Standard Name**: `하이드록시아세토페논`
- **CAS No.**: `99-93-4`
- **EC / EINECS No.**: `202-802-8`
- **Origin**: `synthetic`
- **Functions**: 항산화제
- **Molecular Formula / MW**: `C8H8O2` (136.15 g/mol)

## 1. 7-Track Official Regulatory Label Names
| Track | Official Label Nomenclature |
| :--- | :--- |
| KR (MFDS Standard) | 하이드록시아세토페논 |
| KR (Former Names) | — |
| EU (CosIng 1223/2009) | HYDROXYACETOPHENONE |
| US (PCPC / MoCRA INCI) | HYDROXYACETOPHENONE |
| US (FDA OTC Monograph) | — |
| CN (NMPA IECIC) | 对羟基苯乙酮 |
| JP (JCIA / MHLW QD) | HYDROXYACETOPHENONE  |

## 2. Layer 1 — Global 6-Region Statutory Summary
- **KR (MFDS)**: `none`
- **EU (1223/2009)**: `none`
- **US (FDA/MoCRA)**: `none`
- **CN (NMPA IECIC)**: `allowed` (Entry: `2021`)
- **JP (MHLW)**: `none`
- **ASEAN (ACD)**: `none`



## 3. Layer 2 — Toxicological & Historical Safe Use Concentrations
- **cn_iecic_max** (leave_on): ≤ 2.5% — NMPA IECIC (2025) Entry 05226 (2025)
- **cn_iecic_max** (rinse_off): ≤ 2.3% — NMPA IECIC (2025) Entry 05226 (2025)

## 4. Layer 3 — Formulation Quartiles & Compatibility
- **Optimal pH Window**: 3 – 9
- **Max Process Temp**: ≤ 85°C
- **Synergy Pairings**: 1,2-HEXANEDIOL, CAPRYLYL GLYCOL, ETHYLHEXYLGLYCERIN, SODIUM PHYTATE
- **Incompatibilities**: May develop slight yellowish tint above pH 8.0 or with trace iron ions; combine with chelating agent

## 5. Academic Monograph
■ [1. Chemical Identity & International Labeling Nomenclature]
  - INCI Name: HYDROXYACETOPHENONE | CAS No.: 99-93-4 | EC No.: 202-802-8
  - Origin: SYNTHETIC | Functions: 
  - Physicochemical Profile: Formula C8H8O2 | MW 136.15 g/mol | LogP 1.35 | Ionic Nature: non-ionic | PubChem CID 7469
  - Official Regional Label Names: US [HYDROXYACETOPHENONE] · EU [HYDROXYACETOPHENONE] · CN [对羟基苯乙酮] · JP [-] · JP Quasi-Drug [-]
■ [2. Dermatological Mechanism of Action & Functional Role]
  - Hydroxyacetophenone is the organic compound Classified under origin 'synthetic', it acts within the cosmetic vehicle or stratum corneum to deliver  performance and structural formulation stability.
■ [3. Global 6-Jurisdiction Regulatory Status & Safety Limits (Layer 1 & Layer 2)]
  - Regional Summary: KR: NONE | EU: NONE | US: NONE | CN: ALLOWED | JP: NONE | ASEAN: NONE (CN IECIC (2025) Entry No. 2021 (对羟基苯乙酮))
  - No specific Annex prohibition or numeric restriction across the 6 major jurisdictions (Permitted under general GMP safety assessment).
  - Official Safety & Historical Use Concentration (Layer 2): CN_IECIC_2025 (cn_iecic_max, leave_on): Max 2.5% / CN_IECIC_2025 (cn_iecic_max, rinse_off): Max 2.3%
■ [4. Formulation Dosage Guide by Product Category (Layer 3-A)]
  - [aqueous_serum] Typical range: 0.2 ~ 1.0% (Median 0.5%, Ref: Symrise SymSave H Technical Dossier & CN IECIC) — Multifunctional antioxidant, soothing & preservative booster
  - [emulsion_cream] Typical range: 0.3 ~ 1.0% (Median 0.5%, Ref: Symrise SymSave H TDS) — Preservative-free emulsion stabilizer & anti-discoloration agent
■ [5. Formulation Engineering, Stability & Incompatibility Matrix (Layer 3-B)]
  - Addition Phase: Hot Water Phase (70~80°C) or pre-dissolved in 1,2-Hexanediol / Propanediol
  - Optimal pH Range: pH 3.0 ~ 9.0 | Max Process Temp: Max 85°C | Electrolyte Tolerance: HIGH
  - Incompatibility / Caution: May develop slight yellowish tint above pH 8.0 or with trace iron ions; combine with chelating agent
  - Synergy Pairings: 1,2-HEXANEDIOL, CAPRYLYL GLYCOL, ETHYLHEXYLGLYCERIN, SODIUM PHYTATE | Reference Trade Names: SymSave® H
■ [6. Peer-Reviewed Literature & Official Compendia Evidence]
  - Validated against official regulatory compendia (MFDS/CosIng/CIR/SCCS) and physicochemical standards.

## 6. Linked PubMed Literature