# LACTOBIONIC ACID (lactobionic-acid) — Global Cosmetic Regulatory & Formulation Monograph

- **Canonical URL**: https://www.inciname.com/en/ingredients/lactobionic-acid
- **Standard INCI**: `LACTOBIONIC ACID`
- **KR MFDS Standard Name**: `락토바이오닉애씨드`
- **CAS No.**: `96-82-2`
- **EC / EINECS No.**: `202-538-3`
- **Origin**: `synthetic`
- **Functions**: pH조절제, 완충제
- **Molecular Formula / MW**: `—` (— g/mol)

## 1. 7-Track Official Regulatory Label Names
| Track | Official Label Nomenclature |
| :--- | :--- |
| KR (MFDS Standard) | 락토바이오닉애씨드 |
| KR (Former Names) | — |
| EU (CosIng 1223/2009) | LACTOBIONIC ACID |
| US (PCPC / MoCRA INCI) | LACTOBIONIC ACID |
| US (FDA OTC Monograph) | — |
| CN (NMPA IECIC) | 乳糖酸 |
| JP (JCIA / MHLW QD) | LACTOBIONIC ACID  |

## 2. Layer 1 — Global 6-Region Statutory Summary
- **KR (MFDS)**: `none`
- **EU (1223/2009)**: `none`
- **US (FDA/MoCRA)**: `none`
- **CN (NMPA IECIC)**: `allowed` (Entry: `5692`)
- **JP (MHLW)**: `none`
- **ASEAN (ACD)**: `none`



## 3. Layer 2 — Toxicological & Historical Safe Use Concentrations
- **cn_iecic_max** (leave_on): ≤ 8% — NMPA IECIC (2025) Entry 05692 (2025)
- **cn_iecic_max** (rinse_off): ≤ 5% — NMPA IECIC (2025) Entry 05692 (2025)

## 4. Layer 3 — Formulation Quartiles & Compatibility
- **Optimal pH Window**: 4.5 – 7.5
- **Max Process Temp**: ≤ 70°C
- **Synergy Pairings**: —
- **Incompatibilities**: —

## 5. Academic Monograph
Lactobionic acid is a chemical peeling ingredient that enhances facial skin hydration and elasticity in women aged 30-40 and 50-60 years, with particular effectiveness in improving skin hydration in women aged 50-60.
When used with carboxytherapy, it significantly improves skin elasticity around the eyes with demonstrated effects on R2 and R7 parameters.
It is effective in reducing vascular and pigmentary components of dark circles around the eyes, showing statistically significant improvement in vascular dark circles in the tear trough area.
In a hyaluronic acid-conjugated form, it can be used as an adjunctive therapy to improve ocular surface integrity and reduce drug-induced adverse effects.
It is very well tolerated by all skin types including sensitive skin, demonstrating reduced skin roughness, improved wrinkles, enhanced skin elasticity and firmness.
Through structural and systems biology approaches, skin brightening and UV protection functions have been confirmed, showing alleviated pigmentation and antioxidant effects in zebrafish models.
It is widely used in pharmaceutical, cosmetic, and food industries and can be produced through both chemical oxidation and biotechnological methods using microbial and enzymatic systems.

## 6. Linked PubMed Literature
- [PMID: 41914170] Insights Into the Characterization and Application of Pseudomonas taetrolens — *Front Biosci (Elite Ed)* (2026)
- [PMID: 40871484] Chemical Versus Biological Approaches to the Synthesis of Lactobionic Acid: A Review — *Molecules* (2025)
- [PMID: 40845989] Emulgels powered by coco-glucoside: A stable and effective synbiotics delivery system for skin care — *Int J Pharm* (2025)
- [PMID: 40095547] Influence of Lactobionic Acid on Hydration and Elasticity Parameters in Women Aged 30-40 and 50-60 Years in Comparison to Mandelic Acid — *J Clin Med* (2025)
- [PMID: 39135491] The assessment of the impact of carboxytherapy and selected chemical peels on cosmetic defects and signs of aging of skin around eyes — *J Cosmet Laser Ther* (2024)
- [PMID: 36074189] Supportive treatment to chemotherapy with MMC, in patients with ocular surface squamous neoplasia or conjunctival melanocytic tumor — *J Cancer Res Clin Oncol* (2023)
- [PMID: 35796684] Efficacy and safety of a new peeling formulated with a pool of PHAs for the treatment of all skin types, even sensitive — *J Cosmet Dermatol* (2023)
- [PMID: 35713107] A Novel multi-fruit acids formula design on molecular basis for skin brightening via a system biology approach — *J Cosmet Dermatol* (2022)
- [PMID: 35118861] Efficient Production of Lactobionic Acid Using Escherichia coli Capable of Synthesizing Pyrroloquinoline Quinone — *J Agric Food Chem* (2022)
- [PMID: 35048174] Efficient isolation of new lactobionic acid-producing microorganisms from environmental samples by colloidal calcium carbonate agar plate-based screening — *Bioprocess Biosyst Eng* (2022)
- [PMID: 39193094] The Impact of Carboxytherapy and Treatments Combining Carboxytherapy and Selected Chemical Peels on Vascular and Pigmentary Components of the Dark Circles — *Clin Cosmet Investig Dermatol* (2024)
- [PMID: 37058246] Bioproduction and applications of aldobionic acids with a focus on maltobionic and cellobionic acid — *Bioprocess Biosyst Eng* (2023)