# MADECASSIC ACID (madecassic-acid) — Global Cosmetic Regulatory & Formulation Monograph

- **Canonical URL**: https://www.inciname.com/en/ingredients/madecassic-acid
- **Standard INCI**: `MADECASSIC ACID`
- **KR MFDS Standard Name**: `마데카식애씨드`
- **CAS No.**: `18449-41-7`
- **EC / EINECS No.**: `N/A`
- **Origin**: `synthetic`
- **Functions**: 피부컨디셔닝제
- **Molecular Formula / MW**: `—` (— g/mol)

## 1. 7-Track Official Regulatory Label Names
| Track | Official Label Nomenclature |
| :--- | :--- |
| KR (MFDS Standard) | 마데카식애씨드 |
| KR (Former Names) | — |
| EU (CosIng 1223/2009) | MADECASSIC ACID |
| US (PCPC / MoCRA INCI) | MADECASSIC ACID |
| US (FDA OTC Monograph) | — |
| CN (NMPA IECIC) | 羟基积雪草酸 |
| JP (JCIA / MHLW QD) | MADECASSIC ACID  |

## 2. Layer 1 — Global 6-Region Statutory Summary
- **KR (MFDS)**: `none`
- **EU (1223/2009)**: `none`
- **US (FDA/MoCRA)**: `none`
- **CN (NMPA IECIC)**: `allowed` (Entry: `5263`)
- **JP (MHLW)**: `none`
- **ASEAN (ACD)**: `none`



## 3. Layer 2 — Toxicological & Historical Safe Use Concentrations
- **cn_iecic_max** (leave_on): ≤ 0.8% — NMPA IECIC (2025) Entry 08353 (2025)
- **cn_iecic_max** (rinse_off): ≤ 0.3% — NMPA IECIC (2025) Entry 08353 (2025)

## 4. Layer 3 — Formulation Quartiles & Compatibility
- **Optimal pH Window**: 4.5 – 7.5
- **Max Process Temp**: ≤ 70°C
- **Synergy Pairings**: —
- **Incompatibilities**: —

## 5. Academic Monograph


## 6. Linked PubMed Literature