# MADECASSOSIDE (madecassoside) — Global Cosmetic Regulatory & Formulation Monograph - **Canonical URL**: https://www.inciname.com/en/ingredients/madecassoside - **Standard INCI**: `MADECASSOSIDE` - **KR MFDS Standard Name**: `마데카소사이드` - **CAS No.**: `34540-22-2` - **EC / EINECS No.**: `252-076-1` - **Origin**: `synthetic` - **Functions**: 항산화제, 피부컨디셔닝제 - **Molecular Formula / MW**: `C48H78O20` (975.12 g/mol) ## 1. 7-Track Official Regulatory Label Names | Track | Official Label Nomenclature | | :--- | :--- | | KR (MFDS Standard) | 마데카소사이드 | | KR (Former Names) | — | | EU (CosIng 1223/2009) | MADECASSOSIDE | | US (PCPC / MoCRA INCI) | MADECASSOSIDE | | US (FDA OTC Monograph) | — | | CN (NMPA IECIC) | 羟基积雪草甙 | | JP (JCIA / MHLW QD) | マデカッソシド (QD: マデカッソシド) | ## 2. Layer 1 — Global 6-Region Statutory Summary - **KR (MFDS)**: `none` - **EU (1223/2009)**: `none` - **US (FDA/MoCRA)**: `none` - **CN (NMPA IECIC)**: `allowed` (Entry: `5262`) - **JP (MHLW)**: `none` - **ASEAN (ACD)**: `none` ## 3. Layer 2 — Toxicological & Historical Safe Use Concentrations - **cn_iecic_max** (leave_on): ≤ 2% — NMPA IECIC (2025) Entry 08355 (2025) - **cn_iecic_max** (rinse_off): ≤ 0.5% — NMPA IECIC (2025) Entry 08355 (2025) ## 4. Layer 3 — Formulation Quartiles & Compatibility - **Optimal pH Window**: 4.5 – 7.5 - **Max Process Temp**: ≤ 70°C - **Synergy Pairings**: PANTHENOL, ASIATICOSIDE, ASIATIC ACID, MADECASSIC ACID, CERAMIDE NP, ALLANTOIN - **Incompatibilities**: Water-soluble triterpene glycoside ideal for clear serums; avoid extreme pH (<3.5 or >8.0) and prolonged high heat to prevent glycosidic hydrolysis into insoluble aglycones ## 5. Academic Monograph ■ [1. Chemical Identity & International Labeling Nomenclature] - INCI Name: MADECASSOSIDE | CAS No.: 34540-22-2 | EC No.: 252-076-1 - Origin: SYNTHETIC | Functions: , - Physicochemical Profile: Formula C48H78O20 | MW 975.12 g/mol | LogP -0.9 | Ionic Nature: non-ionic | PubChem CID 45356919 - Official Regional Label Names: US [MADECASSOSIDE] · EU [MADECASSOSIDE] · CN [羟基积雪草甙] · JP [マデカッソシド] · JP Quasi-Drug [マデカッソシド] ■ [2. Dermatological Mechanism of Action & Functional Role] - Major pentacyclic triterpenoid saponin isolated from Centella asiatica. Suppresses NF-κB and MAPK inflammatory cascades (downregulating COX-2, PGE2, TNF-α, IL-1β) while activating the TGF-β/Smad pathway to promote Type I and III collagen synthesis and barrier repair. ■ [3. Global 6-Jurisdiction Regulatory Status & Safety Limits (Layer 1 & Layer 2)] - Regional Summary: KR: NONE | EU: NONE | US: NONE | CN: ALLOWED | JP: NONE | ASEAN: NONE (CN IECIC (2025) Entry No. 5262 (羟基积雪草甙)) - No specific Annex prohibition or numeric restriction across the 6 major jurisdictions (Permitted under general GMP safety assessment). - Official Safety & Historical Use Concentration (Layer 2): CN_IECIC_2025 (cn_iecic_max, leave_on): Max 2.0% / CN_IECIC_2025 (cn_iecic_max, rinse_off): Max 0.5% ■ [4. Formulation Dosage Guide by Product Category (Layer 3-A)] - [aqueous_serum] Typical range: 0.05 ~ 1.0% (Median 0.2%, Ref: SEPPIC Madecassoside Monograph & PubMed Dermatology Trials) — Water-soluble Centella triterpene saponin for barrier soothing & collagen synthesis - [emulsion_cream] Typical range: 0.05 ~ 1.0% (Median 0.2%, Ref: PubMed Centella Triterpenes Review & CN IECIC) — Cica barrier-repair & anti-redness cream active ■ [5. Formulation Engineering, Stability & Incompatibility Matrix (Layer 3-B)] - Addition Phase: Water Phase or Cool-down Phase (< 65°C) - Optimal pH Range: pH 4.5 ~ 7.5 | Max Process Temp: Max 70°C | Electrolyte Tolerance: HIGH - Incompatibility / Caution: Water-soluble triterpene glycoside ideal for clear serums; avoid extreme pH (<3.5 or >8.0) and prolonged high heat to prevent glycosidic hydrolysis into insoluble aglycones - Synergy Pairings: PANTHENOL, ASIATICOSIDE, ASIATIC ACID, MADECASSIC ACID, CERAMIDE NP, ALLANTOIN | Reference Trade Names: Madecassoside 95% (SEPPIC / Bayer), TECA™ ■ [6. Peer-Reviewed Literature & Official Compendia Evidence] - PMID 41421280 (2026, Phytomedicine): Madecassoside attenuated UVB irradiation-induced skin ferroptosis by targeting POR - PMID 41273894 (2026, Colloids Surf B Biointerfaces): Madecassoside-functionalized platinum-based liposomes for sensitive skin: Enhancing rapid soothing and barrier homeostas - PMID 40667819 (2026, Tissue Barriers): Centella asiatica phytochemical Madecassoside enhances skin wound healing and protects against UVB-induced keratinocyte ## 6. Linked PubMed Literature - [PMID: 41421280] Madecassoside attenuated UVB irradiation-induced skin ferroptosis by targeting POR — *Phytomedicine* (2026) - [PMID: 41273894] Madecassoside-functionalized platinum-based liposomes for sensitive skin: Enhancing rapid soothing and barrier homeostasis — *Colloids Surf B Biointerfaces* (2026) - [PMID: 40667819] Centella asiatica phytochemical Madecassoside enhances skin wound healing and protects against UVB-induced keratinocyte damage — *Tissue Barriers* (2026) - [PMID: 40659547] Enhanced Skin-Protective Effects of a Novel Centella asiatica Variety (BT-Care) Cultivated for 75 Days via Modulation of Antioxidant Defense, Collagen Synthesis, and Skin Barrier Function — *J Microbiol Biotechnol* (2025) - [PMID: 41007180] Validation of Madecassoside Synergy Significantly Enhanced Cryptotanshinone's Therapeutic Efficacy Against Acne Vulgaris — *Bioengineering (Basel)* (2025) - [PMID: 42280293] Geroprotective Potential of Centella asiatica: Modulation of Cellular Aging — *Nutrients* (2026) - [PMID: 41683503] Centella asiatica as a Model Biomass for Sustainable Production of Biochemicals via Green Extraction and Purification Technologies: A Comprehensive Field-to-Market Review — *Molecules* (2026) - [PMID: 41025315] Transfersomal delivery of Centella asiatica promotes efficient excision wound healing in rats — *Drug Deliv* (2025) - [PMID: 40957858] A Split-Face Randomized Study on the Efficacy of a Platinum-Liposome-Based Facial Mask Containing Soothing Ingredients for Post-Photorejuvenation Skin Recovery — *J Cosmet Dermatol* (2025) - [PMID: 40848428] A biomimetic multifunctional dressing based on stratum corneum microstructure: integrating antibacterial barrier and breathability for enhanced wound healing — *Biomaterials* (2026) - [PMID: 40613435] Evaluation of the Efficacy and Safety of a Panthenol-Enriched Mask for Skin Barrier Recovery After Facial Laser Treatment: Results of a Double-Blind Randomized Controlled Study — *J Cosmet Dermatol* (2025) - [PMID: 40612277] A dual-component particulate dressing for simultaneous microenvironment modulation and tissue regeneration in infected diabetic wounds — *Mater Today Bio* (2025)