# SODIUM CHLORIDE (sodium-chloride) — Global Cosmetic Regulatory & Formulation Monograph

- **Canonical URL**: https://www.inciname.com/en/ingredients/sodium-chloride
- **Standard INCI**: `SODIUM CHLORIDE`
- **KR MFDS Standard Name**: `소듐클로라이드`
- **CAS No.**: `7647-14-5`
- **EC / EINECS No.**: `231-598-3`
- **Origin**: `mineral`
- **Functions**: 향료, 점도조절제, 증량제, 구강관리제
- **Molecular Formula / MW**: `—` (— g/mol)

## 1. 7-Track Official Regulatory Label Names
| Track | Official Label Nomenclature |
| :--- | :--- |
| KR (MFDS Standard) | 소듐클로라이드 |
| KR (Former Names) | — |
| EU (CosIng 1223/2009) | SODIUM CHLORIDE |
| US (PCPC / MoCRA INCI) | SODIUM CHLORIDE |
| US (FDA OTC Monograph) | — |
| CN (NMPA IECIC) | 氯化钠 |
| JP (JCIA / MHLW QD) | SODIUM CHLORIDE  |

## 2. Layer 1 — Global 6-Region Statutory Summary
- **KR (MFDS)**: `none`
- **EU (1223/2009)**: `none`
- **US (FDA/MoCRA)**: `none`
- **CN (NMPA IECIC)**: `allowed` (Entry: `4517`)
- **JP (MHLW)**: `none`
- **ASEAN (ACD)**: `none`



## 3. Layer 2 — Toxicological & Historical Safe Use Concentrations
- Listed within general cosmetic GMP safety thresholds.

## 4. Layer 3 — Formulation Quartiles & Compatibility
- **Optimal pH Window**: 4 – 8
- **Max Process Temp**: ≤ 50°C
- **Synergy Pairings**: GLYCERIN, CAPRYLIC/CAPRIC TRIGLYCERIDE, TOCOPHEROL
- **Incompatibilities**: Verify phase compatibility under extreme pH or high electrolyte loads

## 5. Academic Monograph
■ [1. Chemical Identity & International Labeling Nomenclature]
  - INCI Name: SODIUM CHLORIDE | CAS No.: 7647-14-5 | EC No.: 231-598-3
  - Origin: MINERAL | Functions: , , , 
  - Physicochemical Profile: Formula      | MW /(Polymer/Complex) | /   | Ionic Nature: non-ionic | CosIng/MFDS 
  - Official Regional Label Names: US [SODIUM CHLORIDE] · EU [SODIUM CHLORIDE] · CN [氯化钠] · JP [-] · JP Quasi-Drug [-]
■ [2. Dermatological Mechanism of Action & Functional Role]
  - SODIUM CHLORIDE functions primarily as , , ,  in dermatological and cosmetic formulations. Classified under origin 'mineral', it acts within the cosmetic vehicle or stratum corneum to deliver , , ,  performance and structural formulation stability.
■ [3. Global 6-Jurisdiction Regulatory Status & Safety Limits (Layer 1 & Layer 2)]
  - Regional Summary: KR: NONE | EU: NONE | US: NONE | CN: ALLOWED | JP: NONE | ASEAN: NONE (CN IECIC (2025) Entry No. 4517 (氯化钠))
  - No specific Annex prohibition or numeric restriction across the 6 major jurisdictions (Permitted under general GMP safety assessment).
  - Official Safety & Historical Use Concentration (Layer 2): Quantum satis (QS) within standard cosmetic safety margins
■ [4. Formulation Dosage Guide by Product Category (Layer 3-A)]
  - [aqueous_serum] Typical range: 0.1 ~ 1.0% (Median 0.8%, Ref: Global Starter Formulation Library Statistical Distribution (n=7, EVONIK 4 · GRANT 3)) — Aqueous serum, toner & hydrogel matrix formulation component
  - [cleanser_rinse] Typical range: 0.15 ~ 2.5% (Median 0.7%, Ref: Global Starter Formulation Library Statistical Distribution (n=27, EVONIK 19 · GRANT 5 · SEPPIC 3)) — Rinse-off cleanser & surfactant system modifier
  - [emulsion_cream] Typical range: 0.05 ~ 1.0% (Median 0.5%, Ref: Global Starter Formulation Library Statistical Distribution (n=24, EVONIK 19 · GRANT 4 · SEPPIC 1)) — Emulsion cream & lotion structural / conditioning agent
■ [5. Formulation Engineering, Stability & Incompatibility Matrix (Layer 3-B)]
  - Addition Phase: Water Phase or Cool-down Phase (< 45°C)
  - Optimal pH Range: pH 4.0 ~ 8.0 | Max Process Temp: Max 50°C | Electrolyte Tolerance: MEDIUM
  - Incompatibility / Caution: Verify phase compatibility under extreme pH or high electrolyte loads
  - Synergy Pairings: GLYCERIN, CAPRYLIC/CAPRIC TRIGLYCERIDE, TOCOPHEROL | Reference Trade Names: SODIUM CHLORIDE
■ [6. Peer-Reviewed Literature & Official Compendia Evidence]
  - PMID 42065368 (2026, Adv Skin Wound Care): Topical Table Salt for the Treatment of Pyogenic Granuloma: A Five-Case Series
  - PMID 42031252 (2026, Int J Biol Macromol): Salt-stable ZnO nanoparticles stabilized by citric-acid-crosslinked Canna edulis ker. starch
  - PMID 41841175 (2026, Physiol Plant): Nano ZnO Alleviates Salt Stress in Rapeseed Seedlings via Ionic Homeostasis and Antioxidant Enhancement

## 6. Linked PubMed Literature
- [PMID: 42065368] Topical Table Salt for the Treatment of Pyogenic Granuloma: A Five-Case Series — *Adv Skin Wound Care* (2026)
- [PMID: 42031252] Salt-stable ZnO nanoparticles stabilized by citric-acid-crosslinked Canna edulis ker. starch — *Int J Biol Macromol* (2026)
- [PMID: 41841175] Nano ZnO Alleviates Salt Stress in Rapeseed Seedlings via Ionic Homeostasis and Antioxidant Enhancement — *Physiol Plant* (2026)
- [PMID: 41837825] Accidental Entry of Ointment in Anterior Chamber Postcataract Surgery: A Clinical Conundrum — *Ann Afr Med* (2026)
- [PMID: 41705606] Airborne Halophilic and Non-Halophilic Microbial Communities in an Underground Salt Mine Affected by Seasonal Environmental Fluctuations — *Environ Microbiol Rep* (2026)
- [PMID: 42053622] Treatment of umbilical granuloma with table salt — *Ned Tijdschr Geneeskd* (2026)
- [PMID: 41781459] Electrochemical characterisation of new textile electrodes based on a conductive silicon yarn for bioelectrical stimulation — *Sci Rep* (2026)
- [PMID: 41699701] Xanthelasma-Like Reaction Following Poly-L-Lactic Acid Intradermal Injection Managed With Fractional Non-Ablative Lasers and Stem Cell-Derived Conditioned Media: A Case Report — *J Cosmet Dermatol* (2026)
- [PMID: 41629402] Nutrient-free biorefinery of corn steep water into lactic acid by Bacillus licheniformis OP16-2 under thermo-alkaline conditions with a pilot-scale assessment — *Sci Rep* (2026)
- [PMID: 42312026] High-salt diet promotes atopic dermatitis by partially enhancing intestinal SGK1/ENaC signaling and destroying gut Lactobacillus-maintained systemic type 1 interferon — *Front Cell Infect Microbiol* (2026)
- [PMID: 42167389] Risk of skin cancer from hydrochlorothiazide and other diuretics across races: A global cohort study — *Environ Toxicol Pharmacol* (2026)
- [PMID: 41975610] Regulation of Storage Reserve Mobilization and Energy Metabolism in Castor Seeds via ZnO-NPs Priming Under Salt Stress — *Physiol Plant* (2026)