# SODIUM PHYTATE (sodium-phytate) — Global Cosmetic Regulatory & Formulation Monograph

- **Canonical URL**: https://www.inciname.com/en/ingredients/sodium-phytate
- **Standard INCI**: `SODIUM PHYTATE`
- **KR MFDS Standard Name**: `소듐파이테이트`
- **CAS No.**: `14306-25-3`
- **EC / EINECS No.**: `238-242-6`
- **Origin**: `synthetic`
- **Functions**: 킬레이트제, 구강관리제
- **Molecular Formula / MW**: `C6H6Na12O24P6` (923.8 g/mol)

## 1. 7-Track Official Regulatory Label Names
| Track | Official Label Nomenclature |
| :--- | :--- |
| KR (MFDS Standard) | 소듐파이테이트 |
| KR (Former Names) | — |
| EU (CosIng 1223/2009) | SODIUM PHYTATE |
| US (PCPC / MoCRA INCI) | SODIUM PHYTATE |
| US (FDA OTC Monograph) | — |
| CN (NMPA IECIC) | 植酸钠 |
| JP (JCIA / MHLW QD) | SODIUM PHYTATE  |

## 2. Layer 1 — Global 6-Region Statutory Summary
- **KR (MFDS)**: `none`
- **EU (1223/2009)**: `none`
- **US (FDA/MoCRA)**: `none`
- **CN (NMPA IECIC)**: `allowed` (Entry: `8594`)
- **JP (MHLW)**: `none`
- **ASEAN (ACD)**: `none`



## 3. Layer 2 — Toxicological & Historical Safe Use Concentrations
- **cn_iecic_max** (leave_on): ≤ 1% — NMPA IECIC (2025) Entry 08612 (2025)
- **cn_iecic_max** (rinse_off): ≤ 0.5% — NMPA IECIC (2025) Entry 08612 (2025)

## 4. Layer 3 — Formulation Quartiles & Compatibility
- **Optimal pH Window**: 3.5 – 9
- **Max Process Temp**: ≤ 85°C
- **Synergy Pairings**: TOCOPHEROL, 3-O-ETHYL ASCORBIC ACID, BAKUCHIOL, HYDROXYACETOPHENONE
- **Incompatibilities**: Strongly alkaline in raw solution (pH ~11); adjust final batch pH with Citric Acid; Do not use with Copper Tripeptide-1 (GHK-Cu), as it chelates Cu2+ away from the peptide

## 5. Academic Monograph
■ [1. Chemical Identity & International Labeling Nomenclature]
  - INCI Name: SODIUM PHYTATE | CAS No.: 14306-25-3 | EC No.: 238-242-6
  - Origin: SYNTHETIC | Functions: , 
  - Physicochemical Profile: Formula C6H6Na12O24P6 | MW 923.8 g/mol | /   | Ionic Nature: anionic | PubChem CID 23676745
  - Official Regional Label Names: US [SODIUM PHYTATE] · EU [SODIUM PHYTATE] · CN [植酸钠] · JP [-] · JP Quasi-Drug [-]
■ [2. Dermatological Mechanism of Action & Functional Role]
  - Myo-Inositol, hexakis(dihydrogen phosphate), sodium salt Classified under origin 'synthetic', it acts within the cosmetic vehicle or stratum corneum to deliver ,  performance and structural formulation stability.
■ [3. Global 6-Jurisdiction Regulatory Status & Safety Limits (Layer 1 & Layer 2)]
  - Regional Summary: KR: NONE | EU: NONE | US: NONE | CN: ALLOWED | JP: NONE | ASEAN: NONE (CN IECIC (2025) Entry No. 8594 (植酸钠))
  - No specific Annex prohibition or numeric restriction across the 6 major jurisdictions (Permitted under general GMP safety assessment).
  - Official Safety & Historical Use Concentration (Layer 2): CN_IECIC_2025 (cn_iecic_max, leave_on): Max 1.0% / CN_IECIC_2025 (cn_iecic_max, rinse_off): Max 0.5%
■ [4. Formulation Dosage Guide by Product Category (Layer 3-A)]
  - [aqueous_serum] Typical range: 0.05 ~ 0.3% (Median 0.1%, Ref: Evonik Dermofeel PA-3 TDS & CIR Phytic Acid/Salts Assessment) — 100% bio-based biodegradable chelating agent (Clean-beauty EDTA replacement)
  - [emulsion_cream] Typical range: 0.05 ~ 0.5% (Median 0.1%, Ref: Evonik Dermofeel PA-3 Technical Dossier) — COSMOS-approved metal-ion sequestrant & antioxidant synergist
■ [5. Formulation Engineering, Stability & Incompatibility Matrix (Layer 3-B)]
  - Addition Phase: Water Phase (Add before pH adjustment)
  - Optimal pH Range: pH 3.5 ~ 9.0 | Max Process Temp: Max 85°C | Electrolyte Tolerance: NONE
  - Incompatibility / Caution: Strongly alkaline in raw solution (pH ~11); adjust final batch pH with Citric Acid
  - Incompatibility / Caution: Do not use with Copper Tripeptide-1 (GHK-Cu), as it chelates Cu2+ away from the peptide
  - Synergy Pairings: TOCOPHEROL, 3-O-ETHYL ASCORBIC ACID, BAKUCHIOL, HYDROXYACETOPHENONE | Reference Trade Names: dermofeel® PA-3
■ [6. Peer-Reviewed Literature & Official Compendia Evidence]
  - PMID 39046084 (2024, Int J Toxicol): Safety Assessment of Polyol Phosphates as Used in Cosmetics.

## 6. Linked PubMed Literature
- [PMID: 39046084] Safety Assessment of Polyol Phosphates as Used in Cosmetics. — *Int J Toxicol* (2024)