# ZINC PCA (zinc-pca) — Global Cosmetic Regulatory & Formulation Monograph

- **Canonical URL**: https://www.inciname.com/en/ingredients/zinc-pca
- **Standard INCI**: `ZINC PCA`
- **KR MFDS Standard Name**: `징크피씨에이`
- **CAS No.**: `68107-75-5`
- **EC / EINECS No.**: `268-475-9`
- **Origin**: `synthetic`
- **Functions**: 보습제, 피부컨디셔닝제
- **Molecular Formula / MW**: `C10H12N2O6Zn` (321.58 g/mol)

## 1. 7-Track Official Regulatory Label Names
| Track | Official Label Nomenclature |
| :--- | :--- |
| KR (MFDS Standard) | 징크피씨에이 |
| KR (Former Names) | — |
| EU (CosIng 1223/2009) | ZINC PCA |
| US (PCPC / MoCRA INCI) | ZINC PCA |
| US (FDA OTC Monograph) | — |
| CN (NMPA IECIC) | PCA 锌 |
| JP (JCIA / MHLW QD) | ZINC PCA  |

## 2. Layer 1 — Global 6-Region Statutory Summary
- **KR (MFDS)**: `restricted`
- **EU (1223/2009)**: `restricted`
- **US (FDA/MoCRA)**: `none`
- **CN (NMPA IECIC)**: `allowed` (Entry: `429`)
- **JP (MHLW)**: `none`
- **ASEAN (ACD)**: `none`



## 3. Layer 2 — Toxicological & Historical Safe Use Concentrations
- **cn_iecic_max** (leave_on): ≤ 2% — NMPA IECIC (2025) Entry 00712 (2025)
- **cn_iecic_max** (rinse_off): ≤ 1% — NMPA IECIC (2025) Entry 00712 (2025)

## 4. Layer 3 — Formulation Quartiles & Compatibility
- **Optimal pH Window**: 4.5 – 6.5
- **Max Process Temp**: ≤ 70°C
- **Synergy Pairings**: NIACINAMIDE, SUCCINIC ACID, SALICYLIC ACID, XANTHAN GUM, POLYACRYLATE CROSSPOLYMER-6
- **Incompatibilities**: Divalent Zn2+ ion immediately collapses standard Carbomer gels; use Xanthan Gum, Sclerotium Gum, HEC, or SEPIMAX ZEN; Precipitates as insoluble Zinc Hydroxide above pH 7.0; maintain pH 4.8~6.0

## 5. Academic Monograph
■ [1. Chemical Identity & International Labeling Nomenclature]
  - INCI Name: ZINC PCA | CAS No.: 68107-75-5 | EC No.: 268-475-9
  - Origin: SYNTHETIC | Functions: , 
  - Physicochemical Profile: Formula C10H12N2O6Zn | MW 321.58 g/mol | /   | Ionic Nature: cationic | PubChem CID 115221
  - Official Regional Label Names: US [ZINC PCA] · EU [ZINC PCA] · CN [PCA 锌] · JP [-] · JP Quasi-Drug [-]
■ [2. Dermatological Mechanism of Action & Functional Role]
  - ZINC PCA functions primarily as ,  in dermatological and cosmetic formulations. Classified under origin 'synthetic', it acts within the cosmetic vehicle or stratum corneum to deliver ,  performance and structural formulation stability.
■ [3. Global 6-Jurisdiction Regulatory Status & Safety Limits (Layer 1 & Layer 2)]
  - Regional Summary: KR: RESTRICTED | EU: RESTRICTED | US: NONE | CN: ALLOWED | JP: NONE | ASEAN: NONE (CN IECIC (2025) Entry No. 429 (PCA 锌))
  - [KR / COMPOSITION / limited] (Max 1%): 
  - [EU / COMPOSITION / limited] (Max 1%): 
  - Official Safety & Historical Use Concentration (Layer 2): CN_IECIC_2025 (cn_iecic_max, leave_on): Max 2.0% / CN_IECIC_2025 (cn_iecic_max, rinse_off): Max 1.0%
■ [4. Formulation Dosage Guide by Product Category (Layer 3-A)]
  - [aqueous_serum] Typical range: 0.1 ~ 1.0% (Median 0.5%, Ref: Solabia Zincidone / Ajinomoto Ajidew ZN-100 TDS & CIR Assessment) — 5α-reductase sebum inhibitor, anti-acne antimicrobial & physiological humectant
■ [5. Formulation Engineering, Stability & Incompatibility Matrix (Layer 3-B)]
  - Addition Phase: Water Phase (< 60°C)
  - Optimal pH Range: pH 4.5 ~ 6.5 | Max Process Temp: Max 70°C | Electrolyte Tolerance: NONE
  - Incompatibility / Caution: Divalent Zn2+ ion immediately collapses standard Carbomer gels; use Xanthan Gum, Sclerotium Gum, HEC, or SEPIMAX ZEN
  - Incompatibility / Caution: Precipitates as insoluble Zinc Hydroxide above pH 7.0; maintain pH 4.8~6.0
  - Synergy Pairings: NIACINAMIDE, SUCCINIC ACID, SALICYLIC ACID, XANTHAN GUM, POLYACRYLATE CROSSPOLYMER-6 | Reference Trade Names: Zincidone® (Solabia), Ajidew® ZN-100
■ [6. Peer-Reviewed Literature & Official Compendia Evidence]
  - PMID 39778065 (2025, J Cosmet Dermatol): A Cohort Clinical Study on the Efficacy of Topical Salicylic Acid/Piroctone Olamine Dandruff Pre-Gel and Cleanser in Imp
  - PMID 35330623 (2022, Clin Cosmet Investig Dermatol): Facial Seborrheic Dermatitis in HIV-Seropositive Patients: Evaluation of the Efficacy and Safety of a Non-Steroidal Crea
  - PMID 33934474 (2021, J Cosmet Dermatol): Treatment of cradle cap in infants with a new cosmetic non-steroidal gel cream: Clinical, laboratory, and instrumental e

## 6. Linked PubMed Literature
- [PMID: 39778065] A Cohort Clinical Study on the Efficacy of Topical Salicylic Acid/Piroctone Olamine Dandruff Pre-Gel and Cleanser in Improving Symptoms of Moderate to Severe Seborrheic Dermatitis of the Scalp — *J Cosmet Dermatol* (2025)
- [PMID: 35330623] Facial Seborrheic Dermatitis in HIV-Seropositive Patients: Evaluation of the Efficacy and Safety of a Non-Steroidal Cream Containing Piroctone Olamine, Biosaccharide Gum-2 and Stearyl Glycyrrhetinate - A Case Series — *Clin Cosmet Investig Dermatol* (2022)
- [PMID: 33934474] Treatment of cradle cap in infants with a new cosmetic non-steroidal gel cream: Clinical, laboratory, and instrumental evaluation — *J Cosmet Dermatol* (2021)
- [PMID: 32574015] Non-Steroidal Topical Therapy for Facial Seborrheic Dermatitis — *J Drugs Dermatol* (2020)
- [PMID: 31705438] Exploring Anti-Fungal, Anti-Microbial and Anti-Inflammatory Properties of a Topical Non-Steroidal Barrier Cream in Face and Chest Seborrheic Dermatitis — *Dermatol Ther (Heidelb)* (2020)
- [PMID: 30774406] Clinical and instrumental evaluation of a new topical non-corticosteroid antifungal/anti-inflammatory/antiseborrheic combination cream for the treatment of mild-to-moderate facial seborrheic dermatitis — *Clin Cosmet Investig Dermatol* (2019)
- [PMID: 21834944] Zinc l-pyrrolidone carboxylate inhibits the UVA-induced production of matrix metalloproteinase-1 by in vitro cultured skin fibroblasts, whereas it enhances their collagen synthesis — *Int J Cosmet Sci* (2012)
- [PMID: 32983333] Efficacy and Tolerability of Topical Nicotinamide Plus Antibacterial Adhesive Agents and Zinc-Pyrrolidone Carboxylic Acid Versus Placebo as an Adjuvant Treatment for Moderate Acne Vulgaris in Indonesia: A Multicenter, Double-blind, Randomized, Controlled Trial — *J Clin Aesthet Dermatol* (2020)
- [PMID: 16871773] The mechanisms of action of nicotinamide and zinc in inflammatory skin disease — *Cutis* (2006)
- [PMID: 29193602] The role of zinc in the treatment of acne: A review of the literature — *Dermatol Ther* (2018)
- [PMID: 32356369] Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha-hydroxy acid) for acne — *Cochrane Database Syst Rev* (2020)
- [PMID: 4123016] Zinc and sebum excretion — *Lancet* (1973)
- [PMID: 159871] Zinc and acne: does it work? — *Int J Dermatol* (1979)
- [PMID: 141314] Zinc, acrodermatitis, acne, and prostaglandins — *Br Med J* (1977)