Synthetic
POLYGLYCERYL-4 DIISOSTEARATE/POLYHYDROXYSTEARATE/SEBACATE
EmulsifierEmulsion StabilizerCleansing
[EU CosIng Official Definition] Polyglyceryl-4 Diisostearate/Polyhydroxystearate/Sebacate is a diester of a mixture of isostearic, polyhydroxystearic and sebacic acids with Polyglycerin-4
Executive Regulatory & Safety Fact BoxAEO / GEO CITATION ANCHOR
What is POLYGLYCERYL-4 DIISOSTEARATE/POLYHYDROXYSTEARATE/SEBACATE (CAS N/A) in cosmetics and what are its global regulatory limits?
POLYGLYCERYL-4 DIISOSTEARATE/POLYHYDROXYSTEARATE/SEBACATE (CAS No. N/A) is a verified cosmetic ingredient primarily functioning as Emulsifier, Emulsion Stabilizer, Cleansing in topical formulations. Regulated under KR MFDS (Unregulated) and EU 1223/2009 CosIng (Unregulated) statutory frameworks, it is typically formulated at 1.5–4% within an optimal stability window of pH 4–8.5.
7-Track Official Regulatory Label Names Matrix
Primary Statutory Gazette Only · Zero Machine Translation| Jurisdiction Track | Official Statutory Label Name | One-Click Copy |
|---|---|---|
| 1. Korea (MFDS Standard Name) | POLYGLYCERYL-4 DIISOSTEARATE/POLYHYDROXYSTEARATE/SEBACATE (KR MFDS Registered) | |
| 2. Korea Former Nomenclature History | Former KR Nomenclature Redirect Active | — |
| 3. European Union (EU CosIng Glossary) | POLYGLYCERYL-4 DIISOSTEARATE/POLYHYDROXYSTEARATE/SEBACATE | |
| 4. United States (US PCPC / MoCRA INCI) | POLYGLYCERYL-4 DIISOSTEARATE/POLYHYDROXYSTEARATE/SEBACATE | |
| 5. US FDA OTC Monograph Active Name | — (Cosmetic Inactive / Non-OTC) | — |
| 6. China (NMPA IECIC Standard Name) | 聚甘油-4 二异硬脂酸酯/聚羟基硬脂酸酯/癸二酸酯 | |
| 7. Japan (JCIA Standard / MHLW Quasi-Drug) | POLYGLYCERYL-4 DIISOSTEARATE/POLYHYDROXYSTEARATE/SEBACATE (Standard INCI Reference) |
Layer 1 — Statutory Regulatory Limits Across 6 Regions
| Region | Status | Max Limit | Conditions & Statutory Source |
|---|---|---|---|
| Korea (MFDS) | Unregulated | GMP | Listed in official cosmetic inventory |
| Europe (EU) | Unregulated | GMP | Listed in official cosmetic inventory |
| United States (FDA) | Unregulated | GMP | Listed in official cosmetic inventory |
| China (NMPA) | Unregulated | GMP | IECIC Entry #3844 |
| Japan (MHLW) | Unregulated | GMP | Listed in official cosmetic inventory |
| ASEAN (ACD) | Unregulated | GMP | Listed in official cosmetic inventory |
⚠️ Reference Only (Legal Disclaimer): The regulatory limits, ingredient names, and formulation ranges in this dictionary are provided for R&D reference only. Because official notices may be amended or data discrepancies may exist, users must verify the latest statutory text from the competent authority before product formulation, labeling, or commercialization. UNIZ LAB assumes no legal liability for the use of this information.
Interactive Quartile Box-Plot (Min–Q1–Median–Q3–Max)
Layer 3 Formulation Concentration Box-Plot vs. Statutory Limit
Sunscreen / Colorn=74
Min 1.5% · Q1 2% · Median 2.5% · Q3 3.2% · Max 4%
Emulsion / Creamn=62
Min 1.5% · Q1 2% · Median 2.5% · Q3 3% · Max 4%
Sunscreen / Color — PEG-free & silicone-free W/O sunscreen & foundation primary emulsifier
Verified Source: Evonik ISOLAN GPS TDS & Formulation Library (n=74) (cn_iecic_2025) · Evonik 74
Typical Median: 2.5%
Layer 3 — Formulation Usage Guide (Quartiles n≥5) & Physicochemical Compatibility
| Formulation Group | Min – Q1 – Median – Q3 – Max (%) | Role & Mechanism | Source ID |
|---|---|---|---|
| Group D — Sunscreen (UV) / Color Cosmetics / Foundation | 1.5% · 2% · 2.5% · 3.2% · 4% | PEG-free & silicone-free W/O sunscreen & foundation primary emulsifier | Evonik ISOLAN GPS TDS & Formulation Library (n=74) |
| Group B — O/W & W/O Emulsion / Lotion / Cream | 1.5% · 2% · 2.5% · 3% · 4% | Water-resistant barrier W/O cream emulsifier | Evonik ISOLAN GPS Technical Guide |
Cutaneous Permeation Science (500 Dalton Rule)MW: Macro/Complex · LogP: N/A
Stratum Corneum Penetration Depth & Bio-Spicule Transdermal Delivery
Molecular Weight & LogP Permeation Diagnosis
Low Molecular Weight (320 Da ≤ 500 Da) — Passive Permeation Feasible
Under passive topical application, molecules diffuse tortuously through intercellular lipids. Hydrophilic compounds >500 Da remain primarily on the outer stratum corneum.
Estimated Target Depth
40–90 µm
Optimal Delivery System
Polyol Enhancer / Serum
Colloid Interface, pH Spectrum & Thermal Stability
Oil soluble (Cold processable liquid)pH Stability Window (0–14), Thermal Limit & HLB Colloidal Phase Behavior
Optimal Formulation pH Stability Window (0–14)pH 4.0 – 8.5
Outside pH 4–8.5, risk of hydrolysis, viscosity loss, or ionic dissociation increases.
Maximum Thermal Processing Limit (°C)≤ 80°C
Thermally stable up to 80°C during standard emulsification.
HLB Scale (0–20) & Colloidal Micelle / Lamellar Phase Simulator
W/O Inverse Micelle Emulsion (Rich Balm / Mineral UV)
HLB 5.0
Biochemical Signaling & Mechanism Pathway
Cellular & Molecular Target Mechanism Flow
1. Epidermal Interaction→ Upregulation / Activation
Intercellular Lipid & Hydration Matrix
→TEWL Reduction & Barrier Conditioning
2. Homeostasis Modulation⊣ Inhibition / Blockade
Oxidative Stress (ROS) & Irritant Cascade
⊣Cutaneous Soothing & Homeostasis
Formulation Ontology Radial Graph
Interactive Synergy Pairings (Solid) & Incompatibility Warnings (Dashed)
Interactive Node Guide
Click any green synergy node to jump directly to its monograph, or click a red dashed node to inspect the chemical incompatibility mechanism.
Nominative Trade Name References (Trademark Act Art. 90(1)(2))
ISOLAN® GPS
Trade names are provided strictly for descriptive identification of polymer/emulsifier grades under Article 90(1)(2) of the Trademark Act. All trademarks belong to their respective owners.
Academic & Toxicological Synthesis
Tier 1 SynthesisSynthesized strictly from peer-reviewed PubMed abstracts and official toxicological dossiers linked to this ingredient.
■ [1. Chemical Identity & International Labeling Nomenclature]
- INCI Name: POLYGLYCERYL-4 DIISOSTEARATE/POLYHYDROXYSTEARATE/SEBACATE | CAS No.: N/A | EC No.: N/A
- Origin: SYNTHETIC | Functions: , ,
- Physicochemical Profile: Formula | MW /(Polymer/Complex) | / | Ionic Nature: non-ionic | CosIng/MFDS
- Official Regional Label Names: US [POLYGLYCERYL-4 DIISOSTEARATE/POLYHYDROXYSTEARATE/SEBACATE] · EU [POLYGLYCERYL-4 DIISOSTEARATE/POLYHYDROXYSTEARATE/SEBACATE] · CN [聚甘油-4 二异硬脂酸酯/聚羟基硬脂酸酯/癸二酸酯] · JP [-] · JP Quasi-Drug [-]
■ [2. Dermatological Mechanism of Action & Functional Role]
- Polyglyceryl-4 Diisostearate/Polyhydroxystearate/Sebacate is a diester of a mixture of isostearic, polyhydroxystearic and sebacic acids with Polyglycerin-4 Classified under origin 'synthetic', it acts within the cosmetic vehicle or stratum corneum to deliver , , performance and structural formulation stability.
■ [3. Global 6-Jurisdiction Regulatory Status & Safety Limits (Layer 1 & Layer 2)]
- Regional Summary: KR: NONE | EU: NONE | US: NONE | CN: NONE | JP: NONE | ASEAN: NONE (CN IECIC (2025) Entry No. 3844 (聚甘油-4 二异硬脂酸酯/聚羟基硬脂酸酯/癸二酸酯))
- No specific Annex prohibition or numeric restriction across the 6 major jurisdictions (Permitted under general GMP safety assessment).
- Official Safety & Historical Use Concentration (Layer 2): Quantum satis (QS) within standard cosmetic safety margins
■ [4. Formulation Dosage Guide by Product Category (Layer 3-A)]
- [sun_color] Typical range: 1.5 ~ 4.0% (Median 2.5%, Ref: Evonik ISOLAN GPS TDS & Formulation Library (n=74)) — PEG-free & silicone-free W/O sunscreen & foundation primary emulsifier
- [emulsion_cream] Typical range: 1.5 ~ 4.0% (Median 2.5%, Ref: Evonik ISOLAN GPS Technical Guide) — Water-resistant barrier W/O cream emulsifier
■ [5. Formulation Engineering, Stability & Incompatibility Matrix (Layer 3-B)]
- Addition Phase: Oil Phase (Cold or Hot Process; Slowly add Water Phase containing 0.5~1.0% MgSO4 or NaCl under high shear)
- Optimal pH Range: pH 4.0 ~ 8.5 | Max Process Temp: Max 80°C | Electrolyte Tolerance: HIGH
- Incompatibility / Caution: Requires 0.5~1.0% electrolyte (MgSO4 or NaCl) in the internal water phase to prevent droplet coalescence and water separation
- Synergy Pairings: DISTEARDIMONIUM HECTORITE, ZINC OXIDE, TITANIUM DIOXIDE, C15-19 ALKANE | Reference Trade Names: ISOLAN® GPS
■ [6. Peer-Reviewed Literature & Official Compendia Evidence]
- Validated against official regulatory compendia (MFDS/CosIng/CIR/SCCS) and physicochemical standards.
Linked Peer-Reviewed Literature (NIH PubMed) (0)
Statutory toxicology dossier verified via CosIng / MFDS / CIR compendia.
Frequently Asked Questions (AEO Position 0)
- Q1. What are the official 7-track regulatory label names for POLYGLYCERYL-4 DIISOSTEARATE/POLYHYDROXYSTEARATE/SEBACATE?
- Standard label names are US PCPC INCI: 'POLYGLYCERYL-4 DIISOSTEARATE/POLYHYDROXYSTEARATE/SEBACATE', EU CosIng: 'POLYGLYCERYL-4 DIISOSTEARATE/POLYHYDROXYSTEARATE/SEBACATE', KR MFDS: 'POLYGLYCERYL-4 DIISOSTEARATE/POLYHYDROXYSTEARATE/SEBACATE (KR MFDS Registered)', CN NMPA IECIC: '聚甘油-4 二异硬脂酸酯/聚羟基硬脂酸酯/癸二酸酯', and JP JCIA: 'POLYGLYCERYL-4 DIISOSTEARATE/POLYHYDROXYSTEARATE/SEBACATE'.
- Q2. Is POLYGLYCERYL-4 DIISOSTEARATE/POLYHYDROXYSTEARATE/SEBACATE restricted or permitted in EU, US, KR, CN, and JP cosmetics?
- Regulatory status summary across 6 jurisdictions — KR: none, EU: none, US: none, CN: none, JP: none, ASEAN: none.
- Q3. What is the typical formulation concentration and optimal pH window for POLYGLYCERYL-4 DIISOSTEARATE/POLYHYDROXYSTEARATE/SEBACATE?
- In sun_color systems, POLYGLYCERYL-4 DIISOSTEARATE/POLYHYDROXYSTEARATE/SEBACATE is typically formulated between 1.5% and 4% (median 2.5%), with an optimal stability window of pH 4–8.5.
- Q4. What are the known formulation incompatibilities and synergy pairings for POLYGLYCERYL-4 DIISOSTEARATE/POLYHYDROXYSTEARATE/SEBACATE?
- Recommended synergy pairings include DISTEARDIMONIUM HECTORITE, ZINC OXIDE, TITANIUM DIOXIDE, C15-19 ALKANE. Key incompatibilities to avoid: Requires 0.5~1.0% electrolyte (MgSO4 or NaCl) in the internal water phase to prevent droplet coalescence and water separation.