What are the official 7-track regulatory label names for POLYACRYLATE CROSSPOLYMER-6?

Standard label names are US PCPC INCI: 'POLYACRYLATE CROSSPOLYMER-6', EU CosIng: 'POLYACRYLATE CROSSPOLYMER-6', KR MFDS: 'POLYACRYLATE CROSSPOLYMER-6 (KR MFDS Registered)', CN NMPA IECIC: '聚丙烯酸酯交联聚合物-6', and JP JCIA: 'POLYACRYLATE CROSSPOLYMER-6'.

Is POLYACRYLATE CROSSPOLYMER-6 restricted or permitted in EU, US, KR, CN, and JP cosmetics?

Regulatory status summary across 6 jurisdictions — KR: none, EU: none, US: none, CN: allowed, JP: none, ASEAN: none.

What is the typical formulation concentration and optimal pH window for POLYACRYLATE CROSSPOLYMER-6?

In aqueous_serum systems, POLYACRYLATE CROSSPOLYMER-6 is typically formulated between 0.15% and 2% (median 0.6%), with an optimal stability window of pH 2–8.

What are the known formulation incompatibilities and synergy pairings for POLYACRYLATE CROSSPOLYMER-6?

Recommended synergy pairings include HYDROLYZED SPONGE, ASCORBIC ACID, TRANEXAMIC ACID, GLYCOLIC ACID, SALICYLIC ACID. Key incompatibilities to avoid: Excessive dosage (>1.2% alone) may cause slight stringiness or pilling; blend with 0.05~0.1% Xanthan Gum for optimal break.

Synthetic

POLYACRYLATE CROSSPOLYMER-6

Viscosity ControllingEmulsion Stabilizer

[EU CosIng Official Definition] Polyacrylate Crosspolymer-6 is a copolymer of ammonium acryloyldimethyltaurate, dimethylacrylamide, lauryl methacrylate and laureth-4 methacrylate, crosslinked with trimethylolpropane triacrylate

Executive Regulatory & Safety Fact BoxAEO / GEO CITATION ANCHOR

What is POLYACRYLATE CROSSPOLYMER-6 (CAS N/A) in cosmetics and what are its global regulatory limits?

POLYACRYLATE CROSSPOLYMER-6 (CAS No. N/A) is a verified cosmetic ingredient primarily functioning as Viscosity Controlling, Emulsion Stabilizer in topical formulations. Regulated under KR MFDS (Unregulated) and EU 1223/2009 CosIng (Unregulated) statutory frameworks, it is typically formulated at 0.15–2% within an optimal stability window of pH 2–8.

7-Track Official Regulatory Label Names Matrix

Primary Statutory Gazette Only · Zero Machine Translation

7-Track Official Statutory Label Names for POLYACRYLATE CROSSPOLYMER-6
Jurisdiction Track	Official Statutory Label Name	One-Click Copy
1. Korea (MFDS Standard Name)	POLYACRYLATE CROSSPOLYMER-6 (KR MFDS Registered)
2. Korea Former Nomenclature History	—	—
3. European Union (EU CosIng Glossary)	POLYACRYLATE CROSSPOLYMER-6
4. United States (US PCPC / MoCRA INCI)	POLYACRYLATE CROSSPOLYMER-6
5. US FDA OTC Monograph Active Name	— (Cosmetic Inactive / Non-OTC)	—
6. China (NMPA IECIC Standard Name)	聚丙烯酸酯交联聚合物-6
7. Japan (JCIA Standard / MHLW Quasi-Drug)	POLYACRYLATE CROSSPOLYMER-6 (Standard INCI Reference)

Layer 1 — Statutory Regulatory Limits Across 6 Regions

Layer 1 Statutory Regulatory Limits Across 6 Regions for POLYACRYLATE CROSSPOLYMER-6
Region	Status	Max Limit	Conditions & Statutory Source
Korea (MFDS)	Unregulated	GMP	Listed in official cosmetic inventory
Europe (EU)	Unregulated	GMP	Listed in official cosmetic inventory
United States (FDA)	Unregulated	GMP	Listed in official cosmetic inventory
China (NMPA)	Listed / Allowed	GMP	IECIC Entry #3720
Japan (MHLW)	Unregulated	GMP	Listed in official cosmetic inventory
ASEAN (ACD)	Unregulated	GMP	Listed in official cosmetic inventory

Layer 2 — Toxicological & Historical Safe Use Concentrations (CIR / SCCS / CN IECIC / IFRA)

“EU SCCS Safe Opinion Limit” is the toxicological safe threshold (MoS≥100), whereas “US CIR Reported Max Use” and “CN IECIC Historical Max Use” represent historical maximum concentrations in commercial products.

Layer 2 Toxicological & Historical Safe Use Concentrations for POLYACRYLATE CROSSPOLYMER-6
Assessment Basis	Application Scope	Concentration Range	Verdict & Dossier Reference
CN IECIC Historical Max Use	leave_on	≤ 3%	Safe (MoS≥100)NMPA IECIC (2025) Entry 03561 (2025)
CN IECIC Historical Max Use	rinse_off	≤ 2%	Safe (MoS≥100)NMPA IECIC (2025) Entry 03561 (2025)

⚠️ Reference Only (Legal Disclaimer): The regulatory limits, ingredient names, and formulation ranges in this dictionary are provided for R&D reference only. Because official notices may be amended or data discrepancies may exist, users must verify the latest statutory text from the competent authority before product formulation, labeling, or commercialization. UNIZ LAB assumes no legal liability for the use of this information.

Interactive Quartile Box-Plot (Min–Q1–Median–Q3–Max)

Layer 3 Formulation Concentration Box-Plot vs. Statutory Limit

Aqueous Serum / Ampoulen=52

Min 0.15% · Q1 0.4% · Median 0.6% · Q3 1% · Max 2%

Emulsion / Creamn=76

Min 0.15% · Q1 0.3% · Median 0.5% · Q3 0.8% · Max 1.5%

Rinse-off Cleansern=10

Min 0.1% · Q1 0.525% · Median 1.25% · Q3 1.5% · Max 3%

Sunscreen / Colorn=5

Min 0.4% · Q1 0.4% · Median 0.8% · Q3 1.5% · Max 1.5%

Aqueous Serum / Ampoule — Electrolyte-resistant thickener & spicule suspension matrix

Verified Source: SEPPIC SEPIMAX ZEN Technical Data Sheet & CN IECIC (cn_iecic_2025) · SEPPIC 44 · Evonik 8

Typical Median: 0.6%

Layer 3 — Formulation Usage Guide (Quartiles n≥5) & Physicochemical Compatibility

Layer 3 Formulation Concentration Quartiles by Product Category for POLYACRYLATE CROSSPOLYMER-6
Formulation Group	Min – Q1 – Median – Q3 – Max (%)	Role & Mechanism	Source ID
Group A — Aqueous Toner / Serum / Ampoule	0.15% · 0.4% · 0.6% · 1% · 2%	Electrolyte-resistant thickener & spicule suspension matrix	SEPPIC SEPIMAX ZEN Technical Data Sheet & CN IECIC
Group B — O/W & W/O Emulsion / Lotion / Cream	0.15% · 0.3% · 0.5% · 0.8% · 1.5%	Low-pH & high-electrolyte emulsion stabilizer	SEPPIC SEPIMAX ZEN TDS & CN IECIC
Group C — Rinse-Off Cleanser / Shampoo / Body Wash	0.1% · 0.525% · 1.25% · 1.5% · 3%	Rinse-off cleanser & surfactant system modifier	Global Starter Formulation Library Statistical Distribution (n=10, SEPPIC 10)
Group D — Sunscreen (UV) / Color Cosmetics / Foundation	0.4% · 0.4% · 0.8% · 1.5% · 1.5%	Sun care & color cosmetics dispersion / sensory modifier	Global Starter Formulation Library Statistical Distribution (n=5, SEPPIC 5)

Cutaneous Permeation Science (500 Dalton Rule)MW: Macro/Complex · LogP: N/A

Stratum Corneum Penetration Depth & Bio-Spicule Transdermal Delivery

Molecular Weight & LogP Permeation Diagnosis

Low Molecular Weight (320 Da ≤ 500 Da) — Passive Permeation Feasible

Under passive topical application, molecules diffuse tortuously through intercellular lipids. Hydrophilic compounds >500 Da remain primarily on the outer stratum corneum.

Estimated Target Depth

40–90 µm

Optimal Delivery System

Polyol Enhancer / Serum

Colloid Interface, pH Spectrum & Thermal Stability

pH Stability Window (0–14), Thermal Limit & HLB Colloidal Phase Behavior

Water and glycol dispersible (pre-neutralized powder)

Optimal Formulation pH Stability Window (0–14)pH 2.0 – 8.0

Outside pH 2–8, risk of hydrolysis, viscosity loss, or ionic dissociation increases.

Maximum Thermal Processing Limit (°C)≤ 80°C

Thermally stable up to 80°C during standard emulsification.

HLB Scale (0–20) & Colloidal Micelle / Lamellar Phase Simulator

O/W Oil-in-Water Micelle Emulsion (Lotion / Cream)

Simulate HLB:HLB 11.5

Biochemical Signaling & Mechanism Pathway

Cellular & Molecular Target Mechanism Flow

1. Epidermal Interaction→ Upregulation / Activation

Intercellular Lipid & Hydration Matrix

→

TEWL Reduction & Barrier Conditioning

2. Homeostasis Modulation⊣ Inhibition / Blockade

Oxidative Stress (ROS) & Irritant Cascade

⊣

Cutaneous Soothing & Homeostasis

Formulation Ontology Radial Graph

Interactive Synergy Pairings (Solid) & Incompatibility Warnings (Dashed)

Interactive Node Guide

Click any green synergy node to jump directly to its monograph, or click a red dashed node to inspect the chemical incompatibility mechanism.

+ HYDROLYZED SPONGE + ASCORBIC ACID + TRANEXAMIC ACID + GLYCOLIC ACID + SALICYLIC ACID

Nominative Trade Name References (Trademark Act Art. 90(1)(2))

SEPIMAX™ ZEN

Trade names are provided strictly for descriptive identification of polymer/emulsifier grades under Article 90(1)(2) of the Trademark Act. All trademarks belong to their respective owners.

Academic & Toxicological Synthesis

Tier 1 Synthesis

Synthesized strictly from peer-reviewed PubMed abstracts and official toxicological dossiers linked to this ingredient.

■ [1. Chemical Identity & International Labeling Nomenclature] - INCI Name: POLYACRYLATE CROSSPOLYMER-6 | CAS No.: N/A | EC No.: N/A - Origin: SYNTHETIC | Functions: , - Physicochemical Profile: Formula | MW /(Polymer/Complex) | / | Ionic Nature: anionic | CosIng/MFDS - Official Regional Label Names: US [POLYACRYLATE CROSSPOLYMER-6] · EU [POLYACRYLATE CROSSPOLYMER-6] · CN [聚丙烯酸酯交联聚合物-6] · JP [-] · JP Quasi-Drug [-] ■ [2. Dermatological Mechanism of Action & Functional Role] - Polyacrylate Crosspolymer-6 is a copolymer of ammonium acryloyldimethyltaurate, dimethylacrylamide, lauryl methacrylate and laureth-4 methacrylate, crosslinked with trimethylolpropane triacrylate Classified under origin 'synthetic', it acts within the cosmetic vehicle or stratum corneum to deliver , performance and structural formulation stability. ■ [3. Global 6-Jurisdiction Regulatory Status & Safety Limits (Layer 1 & Layer 2)] - Regional Summary: KR: NONE | EU: NONE | US: NONE | CN: ALLOWED | JP: NONE | ASEAN: NONE (CN IECIC (2025) Entry No. 3720 (聚丙烯酸酯交联聚合物-6)) - No specific Annex prohibition or numeric restriction across the 6 major jurisdictions (Permitted under general GMP safety assessment). - Official Safety & Historical Use Concentration (Layer 2): CN_IECIC_2025 (cn_iecic_max, leave_on): Max 3.0% / CN_IECIC_2025 (cn_iecic_max, rinse_off): Max 2.0% ■ [4. Formulation Dosage Guide by Product Category (Layer 3-A)] - [aqueous_serum] Typical range: 0.15 ~ 2.0% (Median 0.6%, Ref: SEPPIC SEPIMAX ZEN Technical Data Sheet & CN IECIC) — Electrolyte-resistant thickener & spicule suspension matrix - [emulsion_cream] Typical range: 0.15 ~ 1.5% (Median 0.5%, Ref: SEPPIC SEPIMAX ZEN TDS & CN IECIC) — Low-pH & high-electrolyte emulsion stabilizer - [cleanser_rinse] Typical range: 0.1 ~ 3.0% (Median 1.25%, Ref: Global Starter Formulation Library Statistical Distribution (n=10, SEPPIC 10)) — Rinse-off cleanser & surfactant system modifier ■ [5. Formulation Engineering, Stability & Incompatibility Matrix (Layer 3-B)] - Addition Phase: Water Phase or Oil Phase dispersion - Optimal pH Range: pH 2.0 ~ 8.0 | Max Process Temp: Max 80°C | Electrolyte Tolerance: HIGH - Incompatibility / Caution: Excessive dosage (>1.2% alone) may cause slight stringiness or pilling; blend with 0.05~0.1% Xanthan Gum for optimal break - Synergy Pairings: HYDROLYZED SPONGE, ASCORBIC ACID, TRANEXAMIC ACID, GLYCOLIC ACID, SALICYLIC ACID | Reference Trade Names: SEPIMAX™ ZEN ■ [6. Peer-Reviewed Literature & Official Compendia Evidence] - PMID 41471047 (2025, Pharmaceutics): Interfacial Molecular Interactions as Determinants of Nanostructural Preservation in Ibuprofen-Loaded Nanoemulsions and

Linked Peer-Reviewed Literature (NIH PubMed) (1)

Interfacial Molecular Interactions as Determinants of Nanostructural Preservation in Ibuprofen-Loaded Nanoemulsions and Nanoemulsion Gels [PMID: 41471047 · 2025]

Tošić A, Randjelović D, Ivković B, Gledović A, Stanković T, Đoković J, Papadimitriou V, Ilić T, Savić SD, Pantelić I · Pharmaceutics (2025)

Background/Objectives : Nanoemulsions (NEs) are highly promising drug delivery systems that can be made user-friendlier by thickening to nanoemulsion gels (NEGs). However, in order to be regulatory accepted, such a transformation requires systematic understanding of the underlying interactions and stabilization mechanisms, especially when the incorporated active pharmaceutical ingredient may infiltrate the stabilizer layer. Methods : NEs with/without ibuprofen were submitted through direct vs. indirect gelation using three different gelling agents (carbomer 980, xanthan gum, or polyacrylate crosspolymer-6). Multi-technique characterization was employed to demonstrate nanoparticle preservation within the gel networks, a point often neglected when studying nanogels. Results : The nanoemulsion with the most favorable properties (55.07 ± 0.82 nm, PDI 0.075 ± 0.022) was successfully transformed into nanoemulgels with all three gelling agents, both by an indirect and direct approach. The combination of Fourier-transform infrared spectroscopy (FT-IR) and differential scanning calorimetry (DSC) revealed complex interactions and electron paramagnetic resonance spectroscopy (EPR)-discerned localization of the small-molecule model drug within the surfactants/co-solvents' microenvironment, while atomic force microscopy (AFM) successfully visualized nanodroplets, with or without the presence of aggregates originating from the applied gelling agent. Conclusions : A series of complementary techniques confirmed the preservation of nanodroplets after transformation while highlighting the potential of novel polyacrylate crosspolymer-6 to produce robust gel network while effectively increasing zeta potential from -11.07 to -30.5 mV and allowing for satisfactory ibuprofen release from nanoparticles.

Frequently Asked Questions (AEO Position 0)

Q1. What are the official 7-track regulatory label names for POLYACRYLATE CROSSPOLYMER-6?: Standard label names are US PCPC INCI: 'POLYACRYLATE CROSSPOLYMER-6', EU CosIng: 'POLYACRYLATE CROSSPOLYMER-6', KR MFDS: 'POLYACRYLATE CROSSPOLYMER-6 (KR MFDS Registered)', CN NMPA IECIC: '聚丙烯酸酯交联聚合物-6', and JP JCIA: 'POLYACRYLATE CROSSPOLYMER-6'.
Q2. Is POLYACRYLATE CROSSPOLYMER-6 restricted or permitted in EU, US, KR, CN, and JP cosmetics?: Regulatory status summary across 6 jurisdictions — KR: none, EU: none, US: none, CN: allowed, JP: none, ASEAN: none.
Q3. What is the typical formulation concentration and optimal pH window for POLYACRYLATE CROSSPOLYMER-6?: In aqueous_serum systems, POLYACRYLATE CROSSPOLYMER-6 is typically formulated between 0.15% and 2% (median 0.6%), with an optimal stability window of pH 2–8.
Q4. What are the known formulation incompatibilities and synergy pairings for POLYACRYLATE CROSSPOLYMER-6?: Recommended synergy pairings include HYDROLYZED SPONGE, ASCORBIC ACID, TRANEXAMIC ACID, GLYCOLIC ACID, SALICYLIC ACID. Key incompatibilities to avoid: Excessive dosage (>1.2% alone) may cause slight stringiness or pilling; blend with 0.05~0.1% Xanthan Gum for optimal break.