聚丙烯酸酯交联聚合物-6 (POLYACRYLATE CROSSPOLYMER-6) 在全球 7 大法域的官方全成分标签名称是什么？

中国 NMPA《已使用化妆品原料目录 (IECIC)》标准中文名为 '聚丙烯酸酯交联聚合物-6'，美国 PCPC 与欧盟 CosIng 标准 INCI 为 'POLYACRYLATE CROSSPOLYMER-6'，日本 JCIA 表示名称为 'POLYACRYLATE CROSSPOLYMER-6'。

聚丙烯酸酯交联聚合物-6 (POLYACRYLATE CROSSPOLYMER-6) 在中、韩、欧、美、日、东盟的法定监管状态 (Layer 1) 如何？

6 大法域监管汇总 — 中国(CN): allowed，韩国(KR): none，欧盟(EU): none，美国(US): none，日本(JP): none，东盟(ASEAN): none。

聚丙烯酸酯交联聚合物-6 (POLYACRYLATE CROSSPOLYMER-6) 的常规配方添加量 (Layer 3) 与最佳稳定 pH 窗口是多少？

在代表性剂型 (aqueous_serum) 中常规添加量为 0.15%–2%（中位数 0.6%），最佳稳定 pH 范围为 2–8。

聚丙烯酸酯交联聚合物-6 (POLYACRYLATE CROSSPOLYMER-6) 有哪些配伍禁忌 (Incompatibilities) 与协同增效组合？

推荐协同组合包括 HYDROLYZED SPONGE, ASCORBIC ACID, TRANEXAMIC ACID, GLYCOLIC ACID, SALICYLIC ACID；配伍禁忌注意：Excessive dosage (>1.2% alone) may cause slight stringiness or pilling; blend with 0.05~0.1% Xanthan Gum for optimal break。

化学合成 (Synthetic)

POLYACRYLATE CROSSPOLYMER-6

中国 NMPA《已使用化妆品原料目录 (IECIC)》标准中文名: 聚丙烯酸酯交联聚合物-6 (序号 #3720)

粘度调节剂乳化稳定剂

[EU CosIng Official Definition] Polyacrylate Crosspolymer-6 is a copolymer of ammonium acryloyldimethyltaurate, dimethylacrylamide, lauryl methacrylate and laureth-4 methacrylate, crosslinked with trimethylolpropane triacrylate

核心法规与安全结论 (Executive Fact Box)AEO / GEO CITATION ANCHOR

化妆品中聚丙烯酸酯交联聚合物-6 (POLYACRYLATE CROSSPOLYMER-6) 的全球法规限值与配方应用标准是什么？

聚丙烯酸酯交联聚合物-6（标准 INCI: POLYACRYLATE CROSSPOLYMER-6，CAS 号: N/A）是化妆品配方中主要用作粘度调节剂, 乳化稳定剂的核心成分。受中国 NMPA（已使用/准用）、韩国 MFDS（未列管）及欧盟 CosIng（未列管）等 6 大法域法定标准监管，常规建议添加量为 0.15–2%（最佳稳定窗口 pH 2–8）。

全球 7 轨官方全成分标签名称对照表

严格采用各国政府官方目录原名 · 严禁机器翻译

7-Track Official Statutory Label Names for POLYACRYLATE CROSSPOLYMER-6
法域与监管轨道	官方公告全成分标准名称	一键复制
① 韩国 (MFDS 化妆品标准名称)	POLYACRYLATE CROSSPOLYMER-6 (KR MFDS Registered)
② 韩国旧名称历史 (301 重定向)	—	—
③ 欧盟 (EU CosIng EC 1223/2009)	POLYACRYLATE CROSSPOLYMER-6
④ 美国普通化妆品 (US PCPC / MoCRA INCI)	POLYACRYLATE CROSSPOLYMER-6
⑤ 美国 OTC 防晒/祛痘专论活性物名称 (FDA OTC)	— (非美国 OTC 专论活性成分 / 普通化妆品原料)	—
⑥ 中国 (NMPA《已使用化妆品原料目录 IECIC》标准中文名)	聚丙烯酸酯交联聚合物-6
⑦ 日本普通化妆品 / 医药部外品 (JCIA / MHLW)	POLYACRYLATE CROSSPOLYMER-6 (标准 INCI 参照)

Layer 1 — 全球 6 大法域法定限值与监管状态

Layer 1 Statutory Regulatory Limits Across 6 Regions for POLYACRYLATE CROSSPOLYMER-6
法域	监管状态	法定限值	适用条件与法定依据来源
韩国 (MFDS)	未列管	GMP	已列入官方化妆品原料目录 (按 GMP 规范使用)
欧盟 (EU)	未列管	GMP	已列入官方化妆品原料目录 (按 GMP 规范使用)
美国 (FDA)	未列管	GMP	已列入官方化妆品原料目录 (按 GMP 规范使用)
中国 (NMPA)	已使用/准用	GMP	IECIC Entry #3720
日本 (MHLW)	未列管	GMP	已列入官方化妆品原料目录 (按 GMP 规范使用)
东盟 (ACD)	未列管	GMP	已列入官方化妆品原料目录 (按 GMP 规范使用)

Layer 2 — 毒理评估与历史最高使用量 (CN IECIC / US CIR / EU SCCS)

“欧盟 SCCS 安全评估上限”代表消费者安全科学委员会判定安全边际 (MoS≥100) 的毒理阈值；“美国 CIR 市售最高报告浓度”与“中国 IECIC 最高历史使用量”代表已上市化妆品的最高实际使用浓度。

Layer 2 Toxicological & Historical Safe Use Concentrations for POLYACRYLATE CROSSPOLYMER-6
安全评估依据	适用范围与剂型	评估浓度范围	评估结论与文献档案
中国 IECIC 最高历史使用量	leave_on	≤ 3%	安全判定 (MoS≥100)NMPA IECIC (2025) Entry 03561 (2025)
中国 IECIC 最高历史使用量	rinse_off	≤ 2%	安全判定 (MoS≥100)NMPA IECIC (2025) Entry 03561 (2025)

⚠️ 仅供参考 (免责声明): 本词典中的原料名称、法规限值与配比指南仅供研发参考。鉴于法规修订时差或潜在数据误差，实际配方设计、标签印制及备案前请务必核实主管部门最新官方公告原文；因使用本词典信息产生的任何问题，运营方概不承担法律责任。

Interactive Quartile Box-Plot (Min–Q1–Median–Q3–Max)

Layer 3 Formulation Concentration Box-Plot vs. Statutory Limit

Aqueous Serum / Ampoulen=52

Min 0.15% · Q1 0.4% · Median 0.6% · Q3 1% · Max 2%

Emulsion / Creamn=76

Min 0.15% · Q1 0.3% · Median 0.5% · Q3 0.8% · Max 1.5%

Rinse-off Cleansern=10

Min 0.1% · Q1 0.525% · Median 1.25% · Q3 1.5% · Max 3%

Sunscreen / Colorn=5

Min 0.4% · Q1 0.4% · Median 0.8% · Q3 1.5% · Max 1.5%

Aqueous Serum / Ampoule — Electrolyte-resistant thickener & spicule suspension matrix

Verified Source: SEPPIC SEPIMAX ZEN Technical Data Sheet & CN IECIC (cn_iecic_2025) · SEPPIC 44 · Evonik 8

Typical Median: 0.6%

Layer 3 — 剂型常规配比指南与理化配伍性

Layer 3 Formulation Concentration Quartiles by Product Category for POLYACRYLATE CROSSPOLYMER-6
剂型分类	Min – Q1 – Median – Q3 – Max (%)	配方作用与机理	Source ID
剂型组 A — 水剂爽肤水 / 精华液 / 安瓶	0.15% · 0.4% · 0.6% · 1% · 2%	Electrolyte-resistant thickener & spicule suspension matrix	SEPPIC SEPIMAX ZEN Technical Data Sheet & CN IECIC
剂型组 B — 乳液 / 面霜 (O/W · W/O)	0.15% · 0.3% · 0.5% · 0.8% · 1.5%	Low-pH & high-electrolyte emulsion stabilizer	SEPPIC SEPIMAX ZEN TDS & CN IECIC
剂型组 C — 淋洗类洁面 / 洗发水 / 沐浴露	0.1% · 0.525% · 1.25% · 1.5% · 3%	Rinse-off cleanser & surfactant system modifier	Global Starter Formulation Library Statistical Distribution (n=10, SEPPIC 10)
剂型组 D — 防晒霜 / 彩妆 / 粉底	0.4% · 0.4% · 0.8% · 1.5% · 1.5%	Sun care & color cosmetics dispersion / sensory modifier	Global Starter Formulation Library Statistical Distribution (n=5, SEPPIC 5)

Cutaneous Permeation Science (500 Dalton Rule)MW: Macro/Complex · LogP: N/A

Stratum Corneum Penetration Depth & Bio-Spicule Transdermal Delivery

Molecular Weight & LogP Permeation Diagnosis

Low Molecular Weight (320 Da ≤ 500 Da) — Passive Permeation Feasible

Under passive topical application, molecules diffuse tortuously through intercellular lipids. Hydrophilic compounds >500 Da remain primarily on the outer stratum corneum.

Estimated Target Depth

40–90 µm

Optimal Delivery System

Polyol Enhancer / Serum

Colloid Interface, pH Spectrum & Thermal Stability

pH Stability Window (0–14), Thermal Limit & HLB Colloidal Phase Behavior

Water and glycol dispersible (pre-neutralized powder)

Optimal Formulation pH Stability Window (0–14)pH 2.0 – 8.0

Outside pH 2–8, risk of hydrolysis, viscosity loss, or ionic dissociation increases.

Maximum Thermal Processing Limit (°C)≤ 80°C

Thermally stable up to 80°C during standard emulsification.

HLB Scale (0–20) & Colloidal Micelle / Lamellar Phase Simulator

O/W Oil-in-Water Micelle Emulsion (Lotion / Cream)

Simulate HLB:HLB 11.5

Biochemical Signaling & Mechanism Pathway

Cellular & Molecular Target Mechanism Flow

1. Epidermal Interaction→ Upregulation / Activation

Intercellular Lipid & Hydration Matrix

→

TEWL Reduction & Barrier Conditioning

2. Homeostasis Modulation⊣ Inhibition / Blockade

Oxidative Stress (ROS) & Irritant Cascade

⊣

Cutaneous Soothing & Homeostasis

Formulation Ontology Radial Graph

Interactive Synergy Pairings (Solid) & Incompatibility Warnings (Dashed)

Interactive Node Guide

Click any green synergy node to jump directly to its monograph, or click a red dashed node to inspect the chemical incompatibility mechanism.

+ HYDROLYZED SPONGE + ASCORBIC ACID + TRANEXAMIC ACID + GLYCOLIC ACID + SALICYLIC ACID

代表性商品名参考 (商标法第90条第1款第2项说明性标示)

SEPIMAX™ ZEN

商品名仅供配方师识别原料规格参考，商标权归各原厂商所有。

学术与毒理综合摘要

Tier 1 Synthesis

本综述严格基于与该原料关联的 NIH PubMed 同行评审文献摘要及官方毒理学评估档案编写。

■ [1. Chemical Identity & International Labeling Nomenclature] - INCI Name: POLYACRYLATE CROSSPOLYMER-6 | CAS No.: N/A | EC No.: N/A - Origin: SYNTHETIC | Functions: , - Physicochemical Profile: Formula | MW /(Polymer/Complex) | / | Ionic Nature: anionic | CosIng/MFDS - Official Regional Label Names: US [POLYACRYLATE CROSSPOLYMER-6] · EU [POLYACRYLATE CROSSPOLYMER-6] · CN [聚丙烯酸酯交联聚合物-6] · JP [-] · JP Quasi-Drug [-] ■ [2. Dermatological Mechanism of Action & Functional Role] - Polyacrylate Crosspolymer-6 is a copolymer of ammonium acryloyldimethyltaurate, dimethylacrylamide, lauryl methacrylate and laureth-4 methacrylate, crosslinked with trimethylolpropane triacrylate Classified under origin 'synthetic', it acts within the cosmetic vehicle or stratum corneum to deliver , performance and structural formulation stability. ■ [3. Global 6-Jurisdiction Regulatory Status & Safety Limits (Layer 1 & Layer 2)] - Regional Summary: KR: NONE | EU: NONE | US: NONE | CN: ALLOWED | JP: NONE | ASEAN: NONE (CN IECIC (2025) Entry No. 3720 (聚丙烯酸酯交联聚合物-6)) - No specific Annex prohibition or numeric restriction across the 6 major jurisdictions (Permitted under general GMP safety assessment). - Official Safety & Historical Use Concentration (Layer 2): CN_IECIC_2025 (cn_iecic_max, leave_on): Max 3.0% / CN_IECIC_2025 (cn_iecic_max, rinse_off): Max 2.0% ■ [4. Formulation Dosage Guide by Product Category (Layer 3-A)] - [aqueous_serum] Typical range: 0.15 ~ 2.0% (Median 0.6%, Ref: SEPPIC SEPIMAX ZEN Technical Data Sheet & CN IECIC) — Electrolyte-resistant thickener & spicule suspension matrix - [emulsion_cream] Typical range: 0.15 ~ 1.5% (Median 0.5%, Ref: SEPPIC SEPIMAX ZEN TDS & CN IECIC) — Low-pH & high-electrolyte emulsion stabilizer - [cleanser_rinse] Typical range: 0.1 ~ 3.0% (Median 1.25%, Ref: Global Starter Formulation Library Statistical Distribution (n=10, SEPPIC 10)) — Rinse-off cleanser & surfactant system modifier ■ [5. Formulation Engineering, Stability & Incompatibility Matrix (Layer 3-B)] - Addition Phase: Water Phase or Oil Phase dispersion - Optimal pH Range: pH 2.0 ~ 8.0 | Max Process Temp: Max 80°C | Electrolyte Tolerance: HIGH - Incompatibility / Caution: Excessive dosage (>1.2% alone) may cause slight stringiness or pilling; blend with 0.05~0.1% Xanthan Gum for optimal break - Synergy Pairings: HYDROLYZED SPONGE, ASCORBIC ACID, TRANEXAMIC ACID, GLYCOLIC ACID, SALICYLIC ACID | Reference Trade Names: SEPIMAX™ ZEN ■ [6. Peer-Reviewed Literature & Official Compendia Evidence] - PMID 41471047 (2025, Pharmaceutics): Interfacial Molecular Interactions as Determinants of Nanostructural Preservation in Ibuprofen-Loaded Nanoemulsions and

关联同行评审文献 (NIH PubMed) (1)

Interfacial Molecular Interactions as Determinants of Nanostructural Preservation in Ibuprofen-Loaded Nanoemulsions and Nanoemulsion Gels [PMID: 41471047 · 2025]

Tošić A, Randjelović D, Ivković B, Gledović A, Stanković T, Đoković J, Papadimitriou V, Ilić T, Savić SD, Pantelić I · Pharmaceutics (2025)

Background/Objectives : Nanoemulsions (NEs) are highly promising drug delivery systems that can be made user-friendlier by thickening to nanoemulsion gels (NEGs). However, in order to be regulatory accepted, such a transformation requires systematic understanding of the underlying interactions and stabilization mechanisms, especially when the incorporated active pharmaceutical ingredient may infiltrate the stabilizer layer. Methods : NEs with/without ibuprofen were submitted through direct vs. indirect gelation using three different gelling agents (carbomer 980, xanthan gum, or polyacrylate crosspolymer-6). Multi-technique characterization was employed to demonstrate nanoparticle preservation within the gel networks, a point often neglected when studying nanogels. Results : The nanoemulsion with the most favorable properties (55.07 ± 0.82 nm, PDI 0.075 ± 0.022) was successfully transformed into nanoemulgels with all three gelling agents, both by an indirect and direct approach. The combination of Fourier-transform infrared spectroscopy (FT-IR) and differential scanning calorimetry (DSC) revealed complex interactions and electron paramagnetic resonance spectroscopy (EPR)-discerned localization of the small-molecule model drug within the surfactants/co-solvents' microenvironment, while atomic force microscopy (AFM) successfully visualized nanodroplets, with or without the presence of aggregates originating from the applied gelling agent. Conclusions : A series of complementary techniques confirmed the preservation of nanodroplets after transformation while highlighting the potential of novel polyacrylate crosspolymer-6 to produce robust gel network while effectively increasing zeta potential from -11.07 to -30.5 mV and allowing for satisfactory ibuprofen release from nanoparticles.

常见问题解答 (FAQ)

Q1. 聚丙烯酸酯交联聚合物-6 (POLYACRYLATE CROSSPOLYMER-6) 在全球 7 大法域的官方全成分标签名称是什么？: 中国 NMPA《已使用化妆品原料目录 (IECIC)》标准中文名为 '聚丙烯酸酯交联聚合物-6'，美国 PCPC 与欧盟 CosIng 标准 INCI 为 'POLYACRYLATE CROSSPOLYMER-6'，日本 JCIA 表示名称为 'POLYACRYLATE CROSSPOLYMER-6'。
Q2. 聚丙烯酸酯交联聚合物-6 (POLYACRYLATE CROSSPOLYMER-6) 在中、韩、欧、美、日、东盟的法定监管状态 (Layer 1) 如何？: 6 大法域监管汇总 — 中国(CN): allowed，韩国(KR): none，欧盟(EU): none，美国(US): none，日本(JP): none，东盟(ASEAN): none。
Q3. 聚丙烯酸酯交联聚合物-6 (POLYACRYLATE CROSSPOLYMER-6) 的常规配方添加量 (Layer 3) 与最佳稳定 pH 窗口是多少？: 在代表性剂型 (aqueous_serum) 中常规添加量为 0.15%–2%（中位数 0.6%），最佳稳定 pH 范围为 2–8。
Q4. 聚丙烯酸酯交联聚合物-6 (POLYACRYLATE CROSSPOLYMER-6) 有哪些配伍禁忌 (Incompatibilities) 与协同增效组合？: 推荐协同组合包括 HYDROLYZED SPONGE, ASCORBIC ACID, TRANEXAMIC ACID, GLYCOLIC ACID, SALICYLIC ACID；配伍禁忌注意：Excessive dosage (>1.2% alone) may cause slight stringiness or pilling; blend with 0.05~0.1% Xanthan Gum for optimal break。