What are the official 7-track regulatory label names for SODIUM PHYTATE?

Standard label names are US PCPC INCI: 'SODIUM PHYTATE', EU CosIng: 'SODIUM PHYTATE', KR MFDS: 'SODIUM PHYTATE (KR MFDS Registered)', CN NMPA IECIC: '植酸钠', and JP JCIA: 'SODIUM PHYTATE'.

Is SODIUM PHYTATE restricted or permitted in EU, US, KR, CN, and JP cosmetics?

Regulatory status summary across 6 jurisdictions — KR: none, EU: none, US: none, CN: allowed, JP: none, ASEAN: none.

What is the typical formulation concentration and optimal pH window for SODIUM PHYTATE?

In aqueous_serum systems, SODIUM PHYTATE is typically formulated between 0.05% and 0.3% (median 0.1%), with an optimal stability window of pH 3.5–9.

What are the known formulation incompatibilities and synergy pairings for SODIUM PHYTATE?

Recommended synergy pairings include TOCOPHEROL, 3-O-ETHYL ASCORBIC ACID, BAKUCHIOL, HYDROXYACETOPHENONE. Key incompatibilities to avoid: Strongly alkaline in raw solution (pH ~11); adjust final batch pH with Citric Acid; Do not use with Copper Tripeptide-1 (GHK-Cu), as it chelates Cu2+ away from the peptide.

Synthetic

SODIUM PHYTATE

ChelatingOral Care

[EU CosIng Official Definition] Myo-Inositol, hexakis(dihydrogen phosphate), sodium salt

Executive Regulatory & Safety Fact BoxAEO / GEO CITATION ANCHOR

What is SODIUM PHYTATE (CAS 14306-25-3) in cosmetics and what are its global regulatory limits?

SODIUM PHYTATE (CAS No. 14306-25-3) is a verified cosmetic ingredient primarily functioning as Chelating, Oral Care in topical formulations. Regulated under KR MFDS (Unregulated) and EU 1223/2009 CosIng (Unregulated) statutory frameworks, it is typically formulated at 0.05–0.3% within an optimal stability window of pH 3.5–9.

7-Track Official Regulatory Label Names Matrix

Primary Statutory Gazette Only · Zero Machine Translation

7-Track Official Statutory Label Names for SODIUM PHYTATE
Jurisdiction Track	Official Statutory Label Name	One-Click Copy
1. Korea (MFDS Standard Name)	SODIUM PHYTATE (KR MFDS Registered)
2. Korea Former Nomenclature History	—	—
3. European Union (EU CosIng Glossary)	SODIUM PHYTATE
4. United States (US PCPC / MoCRA INCI)	SODIUM PHYTATE
5. US FDA OTC Monograph Active Name	— (Cosmetic Inactive / Non-OTC)	—
6. China (NMPA IECIC Standard Name)	植酸钠
7. Japan (JCIA Standard / MHLW Quasi-Drug)	SODIUM PHYTATE (Standard INCI Reference)

Layer 1 — Statutory Regulatory Limits Across 6 Regions

Layer 1 Statutory Regulatory Limits Across 6 Regions for SODIUM PHYTATE
Region	Status	Max Limit	Conditions & Statutory Source
Korea (MFDS)	Unregulated	GMP	Listed in official cosmetic inventory
Europe (EU)	Unregulated	GMP	Listed in official cosmetic inventory
United States (FDA)	Unregulated	GMP	Listed in official cosmetic inventory
China (NMPA)	Listed / Allowed	GMP	IECIC Entry #8594
Japan (MHLW)	Unregulated	GMP	Listed in official cosmetic inventory
ASEAN (ACD)	Unregulated	GMP	Listed in official cosmetic inventory

Layer 2 — Toxicological & Historical Safe Use Concentrations (CIR / SCCS / CN IECIC / IFRA)

“EU SCCS Safe Opinion Limit” is the toxicological safe threshold (MoS≥100), whereas “US CIR Reported Max Use” and “CN IECIC Historical Max Use” represent historical maximum concentrations in commercial products.

Layer 2 Toxicological & Historical Safe Use Concentrations for SODIUM PHYTATE
Assessment Basis	Application Scope	Concentration Range	Verdict & Dossier Reference
CN IECIC Historical Max Use	leave_on	≤ 1%	Safe (MoS≥100)NMPA IECIC (2025) Entry 08612 (2025)
CN IECIC Historical Max Use	rinse_off	≤ 0.5%	Safe (MoS≥100)NMPA IECIC (2025) Entry 08612 (2025)

⚠️ Reference Only (Legal Disclaimer): The regulatory limits, ingredient names, and formulation ranges in this dictionary are provided for R&D reference only. Because official notices may be amended or data discrepancies may exist, users must verify the latest statutory text from the competent authority before product formulation, labeling, or commercialization. UNIZ LAB assumes no legal liability for the use of this information.

Interactive Quartile Box-Plot (Min–Q1–Median–Q3–Max)

Layer 3 Formulation Concentration Box-Plot vs. Statutory Limit

Aqueous Serum / Ampoulen=88

Min 0.05% · Q1 0.05% · Median 0.1% · Q3 0.15% · Max 0.3%

Emulsion / Creamn=112

Min 0.05% · Q1 0.05% · Median 0.1% · Q3 0.2% · Max 0.5%

Aqueous Serum / Ampoule — 100% bio-based biodegradable chelating agent (Clean-beauty EDTA replacement)

Verified Source: Evonik Dermofeel PA-3 TDS & CIR Phytic Acid/Salts Assessment (cir_safety) · Evonik 54 · SEPPIC 34

Typical Median: 0.1%

Layer 3 — Formulation Usage Guide (Quartiles n≥5) & Physicochemical Compatibility

Layer 3 Formulation Concentration Quartiles by Product Category for SODIUM PHYTATE
Formulation Group	Min – Q1 – Median – Q3 – Max (%)	Role & Mechanism	Source ID
Group A — Aqueous Toner / Serum / Ampoule	0.05% · 0.05% · 0.1% · 0.15% · 0.3%	100% bio-based biodegradable chelating agent (Clean-beauty EDTA replacement)	Evonik Dermofeel PA-3 TDS & CIR Phytic Acid/Salts Assessment
Group B — O/W & W/O Emulsion / Lotion / Cream	0.05% · 0.05% · 0.1% · 0.2% · 0.5%	COSMOS-approved metal-ion sequestrant & antioxidant synergist	Evonik Dermofeel PA-3 Technical Dossier

Cutaneous Permeation Science (500 Dalton Rule)MW: 923.8 Da · LogP: N/A

Stratum Corneum Penetration Depth & Bio-Spicule Transdermal Delivery

Molecular Weight & LogP Permeation Diagnosis

Macromolecule (923.8 Da > 500 Da) — Transdermal Booster Required

Co-formulating with 0.1–0.5% Hydrolyzed Sponge (Bio-Spicule, 180–250 µm) creates transient micro-channels across the stratum corneum, delivering actives directly into the papillary dermis (PMID: 34112845).

Estimated Target Depth

180–250 µm

Optimal Delivery System

Bio-Spicule + Liposome

Colloid Interface, pH Spectrum & Thermal Stability

pH Stability Window (0–14), Thermal Limit & HLB Colloidal Phase Behavior

Freely soluble in water

Optimal Formulation pH Stability Window (0–14)pH 3.5 – 9.0

Outside pH 3.5–9, risk of hydrolysis, viscosity loss, or ionic dissociation increases.

Maximum Thermal Processing Limit (°C)≤ 85°C

Thermally stable up to 85°C during standard emulsification.

HLB Scale (0–20) & Colloidal Micelle / Lamellar Phase Simulator

O/W Oil-in-Water Micelle Emulsion (Lotion / Cream)

Simulate HLB:HLB 11.5

Biochemical Signaling & Mechanism Pathway

Cellular & Molecular Target Mechanism Flow

1. Epidermal Interaction→ Upregulation / Activation

Intercellular Lipid & Hydration Matrix

→

TEWL Reduction & Barrier Conditioning

2. Homeostasis Modulation⊣ Inhibition / Blockade

Oxidative Stress (ROS) & Irritant Cascade

⊣

Cutaneous Soothing & Homeostasis

Formulation Ontology Radial Graph

Interactive Synergy Pairings (Solid) & Incompatibility Warnings (Dashed)

Interactive Node Guide

Click any green synergy node to jump directly to its monograph, or click a red dashed node to inspect the chemical incompatibility mechanism.

+ TOCOPHEROL + 3-O-ETHYL ASCORBIC ACID + BAKUCHIOL + HYDROXYACETOPHENONE

Nominative Trade Name References (Trademark Act Art. 90(1)(2))

dermofeel® PA-3

Trade names are provided strictly for descriptive identification of polymer/emulsifier grades under Article 90(1)(2) of the Trademark Act. All trademarks belong to their respective owners.

Academic & Toxicological Synthesis

Tier 1 Synthesis

Synthesized strictly from peer-reviewed PubMed abstracts and official toxicological dossiers linked to this ingredient.

■ [1. Chemical Identity & International Labeling Nomenclature] - INCI Name: SODIUM PHYTATE | CAS No.: 14306-25-3 | EC No.: 238-242-6 - Origin: SYNTHETIC | Functions: , - Physicochemical Profile: Formula C6H6Na12O24P6 | MW 923.8 g/mol | / | Ionic Nature: anionic | PubChem CID 23676745 - Official Regional Label Names: US [SODIUM PHYTATE] · EU [SODIUM PHYTATE] · CN [植酸钠] · JP [-] · JP Quasi-Drug [-] ■ [2. Dermatological Mechanism of Action & Functional Role] - Myo-Inositol, hexakis(dihydrogen phosphate), sodium salt Classified under origin 'synthetic', it acts within the cosmetic vehicle or stratum corneum to deliver , performance and structural formulation stability. ■ [3. Global 6-Jurisdiction Regulatory Status & Safety Limits (Layer 1 & Layer 2)] - Regional Summary: KR: NONE | EU: NONE | US: NONE | CN: ALLOWED | JP: NONE | ASEAN: NONE (CN IECIC (2025) Entry No. 8594 (植酸钠)) - No specific Annex prohibition or numeric restriction across the 6 major jurisdictions (Permitted under general GMP safety assessment). - Official Safety & Historical Use Concentration (Layer 2): CN_IECIC_2025 (cn_iecic_max, leave_on): Max 1.0% / CN_IECIC_2025 (cn_iecic_max, rinse_off): Max 0.5% ■ [4. Formulation Dosage Guide by Product Category (Layer 3-A)] - [aqueous_serum] Typical range: 0.05 ~ 0.3% (Median 0.1%, Ref: Evonik Dermofeel PA-3 TDS & CIR Phytic Acid/Salts Assessment) — 100% bio-based biodegradable chelating agent (Clean-beauty EDTA replacement) - [emulsion_cream] Typical range: 0.05 ~ 0.5% (Median 0.1%, Ref: Evonik Dermofeel PA-3 Technical Dossier) — COSMOS-approved metal-ion sequestrant & antioxidant synergist ■ [5. Formulation Engineering, Stability & Incompatibility Matrix (Layer 3-B)] - Addition Phase: Water Phase (Add before pH adjustment) - Optimal pH Range: pH 3.5 ~ 9.0 | Max Process Temp: Max 85°C | Electrolyte Tolerance: NONE - Incompatibility / Caution: Strongly alkaline in raw solution (pH ~11); adjust final batch pH with Citric Acid - Incompatibility / Caution: Do not use with Copper Tripeptide-1 (GHK-Cu), as it chelates Cu2+ away from the peptide - Synergy Pairings: TOCOPHEROL, 3-O-ETHYL ASCORBIC ACID, BAKUCHIOL, HYDROXYACETOPHENONE | Reference Trade Names: dermofeel® PA-3 ■ [6. Peer-Reviewed Literature & Official Compendia Evidence] - PMID 39046084 (2024, Int J Toxicol): Safety Assessment of Polyol Phosphates as Used in Cosmetics.

Linked Peer-Reviewed Literature (NIH PubMed) (1)

Safety Assessment of Polyol Phosphates as Used in Cosmetics. [PMID: 39046084 · 2024]

Johnson W, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG, Shank RC, Slaga TJ, Snyder PW, Fiume M, Heldreth B · Int J Toxicol (2024)

The Expert Panel for Cosmetic Ingredient Safety (Panel) reviewed the safety of 10 polyol phosphates. Some of the possible functions in cosmetics that are reported for this ingredient group are chelating agents, oral care agents, and skin conditioning agents. The Panel reviewed relevant data relating to the safety of these ingredients under the intended conditions of use in cosmetic formulations, and concluded that Sodium Phytate, Phytic Acid, Phytin, and Trisodium Inositol Triphosphate are safe in cosmetics in the present practices of use and concentration described in the safety assessment. The Panel also concluded that the data are insufficient to determine the safety of the following 6 ingredients as used in cosmetics: Disodium Glucose Phosphate, Manganese Fructose Diphosphate, Sodium Mannose Phosphate, Trisodium Fructose Diphosphate, Xylityl Phosphate, and Zinc Fructose Diphosphate.

Frequently Asked Questions (AEO Position 0)

Q1. What are the official 7-track regulatory label names for SODIUM PHYTATE?: Standard label names are US PCPC INCI: 'SODIUM PHYTATE', EU CosIng: 'SODIUM PHYTATE', KR MFDS: 'SODIUM PHYTATE (KR MFDS Registered)', CN NMPA IECIC: '植酸钠', and JP JCIA: 'SODIUM PHYTATE'.
Q2. Is SODIUM PHYTATE restricted or permitted in EU, US, KR, CN, and JP cosmetics?: Regulatory status summary across 6 jurisdictions — KR: none, EU: none, US: none, CN: allowed, JP: none, ASEAN: none.
Q3. What is the typical formulation concentration and optimal pH window for SODIUM PHYTATE?: In aqueous_serum systems, SODIUM PHYTATE is typically formulated between 0.05% and 0.3% (median 0.1%), with an optimal stability window of pH 3.5–9.
Q4. What are the known formulation incompatibilities and synergy pairings for SODIUM PHYTATE?: Recommended synergy pairings include TOCOPHEROL, 3-O-ETHYL ASCORBIC ACID, BAKUCHIOL, HYDROXYACETOPHENONE. Key incompatibilities to avoid: Strongly alkaline in raw solution (pH ~11); adjust final batch pH with Citric Acid; Do not use with Copper Tripeptide-1 (GHK-Cu), as it chelates Cu2+ away from the peptide.